Studies of neuropeptides in pancreatic beta cell function with special emphasis on islet amyloid polypeptide (IAPP) [PDF]
, 2000 The presence of protein amyloid in pancreas and its association to diabetes was first described 100 years ago in 1901, but was not identified as Islet Amyloid Polypeptide (IAPP) until 1986.
Karlsson, Ella
core
Transcriptional regulation of the IAPP gene in pancreatic beta-cells [PDF]
Islet amyloid polypeptide (IAPP or amylin) is co-secreted with insulin from the pancreatic beta-cells. Transcription of the IAPP gene is controlled by a complex promoter region, spanning from -2798 to +450 relative to the transcriptional start site.
Macfarlane WM, Campbell SC, Shepherd LMA
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Evaluation of anti-IAPP/pro-IAPP reactivity
Islet amyloid polypeptide (IAPP) aggregation in the pancreatic islet damages the beta cells and induces apoptosis via caspase-3 activations, a common finding in type 2 diabetes. This study aims to evaluate the reactivity of 19 different polyclonal antibodies raised against pro-IAPP/IAPP.
openaire +1 more source
Massively parallel quantification of mutational impact on IAPP amyloid formation. [PDF]
Nat CommunBadia M, Batlle C, Bolognesi B.
europepmc +2 more sources
Prion Protein-Derived Cell-Penetrating Peptide Inhibits Type II Diabetes-Associated Islet Amyloid Polypeptide Aggregation and Cytotoxicity. [PDF]
BiochemistryOh Y +8 more
europepmc +1 more source
Structural and morphological dynamics of "on-path" and "off-path" oligomers of human islet amyloid polypeptide. [PDF]
Protein SciWarren D, Sitton J, Kurouski D.
europepmc +1 more source
Physiological Implications of Pancreatic Amyloid Polypeptide Aggregation and Its Inhibition by Melatonin. [PDF]
Int J Mol SciYoo YM, Joo SS.
europepmc +1 more source
Molecular Mechanisms of Islet Amyloid Polypeptide Aggregation: Towards Chemical Strategies to Prevent Amyloid Formation and to Design Non-Aggregating Peptide Therapeutics. [PDF]
Int J Mol SciBousch C +4 more
europepmc +1 more source
Use of Small Organic Molecules to Improve Pancreatic Beta Cell Resilience to IAPP-Induced Proteotoxic Stress. [PDF]
Int J Mol SciValshon K +4 more
europepmc +1 more source
Journal of Air Pollution and HealthIntroduction: Air pollution can trigger the attack in asthmatic patients if uncontrolled. Previous works focused on controlling pollution by proposing algorithms to predict air pollution.
Saif Saad Fakhrulddin +2 more
doaj