Results 21 to 30 of about 13,087 (187)

Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide

Molecular Brain, 2023
The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain.
Cristina Nuñez-Diaz, Dovilė Pocevičiūtė, Nina Schultz, The Netherlands Brain Bank, Charlotte Welinder, Karl Swärd, Malin Wennström   +6 more
doaj   +1 more source

Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates

Frontiers in Molecular Biosciences, 2021
The aggregation of the human islet amyloid polypeptide (IAPP) is associated with diabetes type II. A quantitative understanding of this connection at the molecular level requires that the aggregation mechanism of IAPP is resolved in terms of the ...
Diana C. Rodriguez Camargo, Diana C. Rodriguez Camargo, Sean Chia, Sean Chia, Joseph Menzies, Benedetta Mannini, Benedetta Mannini, Georg Meisl, Martin Lundqvist, Christin Pohl, Katja Bernfur, Veronica Lattanzi, Johnny Habchi, Johnny Habchi, Samuel IA Cohen, Tuomas P. J Knowles, Tuomas P. J Knowles, Michele Vendruscolo, Sara Linse   +18 more
doaj   +1 more source

Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate. [PDF]

PLoS ONE, 2016
Pancreatic amyloid formation by islet amyloid polypeptide (IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta-cells and co-secreted with insulin to maintain glucose homeostasis.
Ingrid C Rulifson, Ping Cao, Li Miao, David Kopecky, Linda Huang, Ryan D White, Kim Samayoa, Jonitha Gardner, Xiaosu Wu, Kui Chen, Trace Tsuruda, Oliver Homann, Helene Baribault, Harvey Yamane, Tim Carlson, Jed Wiltzius, Yang Li   +16 more
doaj   +1 more source

Neutron diffraction reveals sequence-specific membrane insertion of pre-fibrillar islet amyloid polypeptide and inhibition by rifampicin [PDF]

, 2005
Human islet amyloid polypeptide (hIAPP) forms amyloid deposits in non-insulin-dependent diabetes mellitus (NIDDM). Pre-fibrillar hIAPP oligomers (in contrast to monomeric IAPP or mature fibrils) increase membrane permeability, suggesting an important ...
Bradshaw, Jeremy P., Bradshaw, Jeremy, Hauss, T, Ashley, Richard H., Balali-Mood, K, Bradshaw, J. P., Balali-Mood, K., Hauß, Thomas, Ashley, R.H., Balali-Mood, Kia, Ashley, R. A., Ashley, R H, Balali Mood, K., Hau , T., Bradshaw, J.P.   +14 more
core   +1 more source

Inhibition of IAPP and IAPP((20-29)) Fibrillation by Polymeric Nanoparticles [PDF]

, 2010
The fibrillation process of the islet amyloid polypeptide (IAPP) and its fragment (IAPP((20-29))) was studied by means of Thioflavin T (ThT) fluorescence and transmission electron microscopy in the absence and presence of N-isopropylacrylamide:N-tert ...
Lynch, I., Dawson, K. A., Linse, S., Cabaleiro-Lago, C., Linse, Sara, Lynch, I.; id_orcid, Dawson, K.A.   +6 more
core   +3 more sources

Caveolin-1 Modulates Islet Amyloid Polypeptide Expression Through Interaction with TXNIP in Murine Pancreatic β-Cells [PDF]

Biomedicines
Background: Pathological aggregation of islet amyloid polypeptide (IAPP) contributes to β-cell dysfunction in type 2 diabetes. Our previous studies demonstrated that caveolin-1 (Cav-1) deficiency protects β-cells from palmitate-induced apoptosis ...
Liu K, Yang X, Lin S, Lin C, Cai N, Zeng L, Zeng W.   +6 more
europepmc   +2 more sources

Inositols do not prevent IAPP amyloid formation. [PDF]

, 2014
TEM images of (A) IAPP, (B) IAPP + myo-inositol, (C) IAPP + epi-inositol, (D) IAPP + scyllo-inositol and (E)IAPP + chiro-inositol were recorded at the end of the amyloid formation reaction. Scale bars represent 100 nm.
Hui Wang (30400), Daniel P. Raleigh (635276)   +1 more
core   +1 more source

Effect of amylin on expression profiles of circRNAs and mRNAs in brain tissue of Alzheimer's disease mice

陆军军医大学学报, 2023
Objective To investigate the effects of intraperitoneal injection of islet amyloid polypeptide (IAPP) on the expression profiles of circular RNAs (circRNAs) and messenger RNAs (mRNAs) in the brain tissue of Alzheimer's disease (AD) mice and wild-type ...
HOU Mingliang, MA Linqiu, LI Jinping, LI Xiaoxiong   +3 more
doaj   +1 more source

Inositols do not induce a conformational change in IAPP. [PDF]

, 2014
CD spectra of IAPP in the presence of different inositol stereoisomers at the beginning of the amyloid formation reaction (A) and after 300 min incubation (B).
Hui Wang (30400), Daniel P. Raleigh (635276)   +1 more
core   +1 more source

Effect of Copper-Catalyzed Oxidation on the Aggregation of the Islet Amyloid Polypeptide. [PDF]

Antioxidants (Basel)
The islet amyloid polypeptide (IAPP) is a 37-residue peptide hormone secreted by pancreatic β-cells that is known to aggregate into amyloid fibrils. These fibrils accumulate in the pancreatic islets of individuals afflicted with type 2 diabetes and are ...
Amilca O, Nguyen PT, Perquis L, Collin F, Bourgault S.   +4 more
europepmc   +2 more sources