Results 11 to 20 of about 13,087 (187)
Interaction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide. [PDF]
PLoS ONE, 2011 Assembly of amyloid-beta peptide (Aβ) into cytotoxic oligomeric and fibrillar aggregates is believed to be a major pathologic event in Alzheimer's disease (AD) and interfering with Aβ aggregation is an important strategy in the development of novel ...
Nasrollah Rezaei-Ghaleh +4 more
doaj +1 more source
Molecular Neurodegeneration, 2022 Background The pathologic accumulation and aggregation of tau is a hallmark of tauopathies including Alzheimer’s disease (AD). However, the molecular mechanisms mediating tau aggregation in AD remain elusive.
Guoxin Zhang +6 more
doaj +1 more source
Clinical and Experimental Hypertension, 2022 Background The relationship between pulse pressure and prognosis in patients with chronic coronary syndrome (CCS) is contradictory. In the present study, we aimed to examine the relationship between intra-aortic pulse pressure (IAPP) and major adverse ...
Halil Aktas, Murat Gul
doaj +1 more source
Biomolecules, 2023 (1) Background and aims: Amyloidosis due to aggregation of amyloid-β (Aβ42) is a key pathogenic event in Alzheimer’s disease (AD), whereas aggregation of mature islet amyloid polypeptide (IAPP37) in human islets leads to β-cell dysfunction.
Qing-Rong Liu +5 more
doaj +1 more source
General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. [PDF]
PLoS ONE, 2014 Islet amyloid polypeptide (IAPP or amylin) forms amyloid deposits in the islets of Langerhans; a process that is believed to contribute to the progression of type 2 diabetes and to the failure of islet transplants.
Hui Wang, Daniel P Raleigh
doaj +1 more source
Food Science and Human Wellness, 2021 Islet amyloid polypeptide (IAPP), or amylin, has been identified as a key factor in the development of type 2 diabetes (T2D). IAPP aggregates, which form amyloid fibrils, contribute to cytotoxicity of the pancreatic β-cells, resulting in loss of function
Raliat O. Abioye, Chibuike C. Udenigwe
doaj +1 more source
Laser-induced periodic surface structures as optical resonators for organic thin-film distributed feedback lasers [PDF]
EPJ Web of Conferences, 2023 Laser-induced periodic surface structures (LIPSS) have received considerable attention due to their potential for micro-and nanostructuring and surface functionalization of various materials.
Dong Tiange +5 more
doaj +1 more source
Blocking Inflammasome Activation Caused by β-Amyloid Peptide (Aβ) and Islet Amyloid Polypeptide (IAPP) through an IAPP Mimic [PDF]
, 2019 Inflammation in the brain and pancreas is linked to cell degeneration and pathogenesis of both Alzheimer's disease (AD) and type 2 diabetes (T2D). Inflammatory cascades in both tissues are triggered by the uptake of beta-amyloid peptide (A beta) or islet
Jürgen Bernhagen +17 more
core +3 more sources
The Effect of Cholesterol on Membrane-Bound Islet Amyloid Polypeptide
Frontiers in Molecular Biosciences, 2021 Islet amyloid polypeptide (IAPP) is a proposed cause of the decreased beta-cell mass in patients with type-II diabetes. The molecular composition of the cell-membrane is important for regulating IAPP cytotoxicity and aggregation.
Mikkel Christensen +5 more
doaj +1 more source
Frontiers in Microbiology, 2020 Diabetes is a major public health issue that has attained alarming levels worldwide. Pancreatic aggregates of human islet amyloid polypeptide (IAPP) represent a major histopathological hallmark of type 2 diabetes.
Ana F. Raimundo +11 more
doaj +1 more source