Results 21 to 30 of about 10,923 (183)
Amyloid precursor protein in pancreatic islets [PDF]
Journal of Endocrinology, 2017 The amyloid precursor protein (APP) has been extensively investigated for its role in the production of amyloid beta (Aβ), a plaque-forming peptide in Alzheimer’s disease (AD). Epidemiological evidence suggests type 2 diabetes is a risk factor for AD. The pancreas is an essential regulator of blood glucose levels through the secretion of the hormones ...
Joshua A, Kulas +2 more
openaire +2 more sources
Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction
Molecular Metabolism, 2020 Objective: Pancreatic β-cell failure is central to the development and progression of type 2 diabetes (T2D). The aggregation of human islet amyloid polypeptide (hIAPP) has been associated with pancreatic islet inflammation and dysfunction in T2D.
Júlia Rodríguez-Comas +11 more
doaj +1 more source
Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis
Journal of Diabetes Research, 2015 Type II diabetes mellitus is associated with the deposition of fibrillar aggregates in pancreatic islets. The major protein component of islet amyloids is the glucomodulatory hormone islet amyloid polypeptide (IAPP).
Phuong Trang Nguyen +3 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Insulin resistance is the major risk factor for Type 2 diabetes (T2D). In vulnerable individuals, insulin resistance induces a progressive loss of insulin secretion with islet pathology revealing a partial deficit of beta cells and islet amyloid derived ...
Tatyana Gurlo +8 more
doaj +1 more source
Type 2 diabetes mellitus as a prion disease (literature review)
Известия высших учебных заведений. Поволжский регион: Медицинские науки, 2022 Type 2 diabetes mellitus (T2DM) is the most common endocrine disease characterized by impaired insulin, hyperglycemia and chronic insulin resistance due to dysfunction and loss of β-cells of the islets of Largenhans.
A.S. Filimonova +3 more
doaj +1 more source
General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. [PDF]
PLoS ONE, 2014 Islet amyloid polypeptide (IAPP or amylin) forms amyloid deposits in the islets of Langerhans; a process that is believed to contribute to the progression of type 2 diabetes and to the failure of islet transplants.
Hui Wang, Daniel P Raleigh
doaj +1 more source
Frontiers in Microbiology, 2020 Diabetes is a major public health issue that has attained alarming levels worldwide. Pancreatic aggregates of human islet amyloid polypeptide (IAPP) represent a major histopathological hallmark of type 2 diabetes.
Ana F. Raimundo +11 more
doaj +1 more source
Pro Islet Amyloid Polypeptide (ProIAPP) Immunoreactivity in the Islets of Langerhans [PDF]
Upsala Journal of Medical Sciences, 2000 Islet amyloid is typically found in type 2 diabetes mellitus and is believed to participate in the beta cell deterioration. The islet amyloid fibril consists of the 37-amino-acid islet amyloid polypeptide (IAPP) but its pathogenesis is only partly understood.
G T, Westermark +4 more
openaire +2 more sources
Cell Transplantation, 2016 Clinical islet transplantation is characterized by a progressive deterioration of islet graft function, which renders many patients once again dependent on exogenous insulin administration within a couple of years.
Hanna Liljebäck +3 more
doaj +1 more source
Role and Cytotoxicity of Amylin and Protection of Pancreatic Islet β-Cells from Amylin Cytotoxicity
Cells, 2018 Amylin, (or islet amyloid polypeptide; IAPP), a 37-amino acid peptide hormone, is released in response to nutrients, including glucose, lipids or amino acids. Amylin is co-stored and co-secreted with insulin by pancreatic islet β-cells.
Yoshimitsu Kiriyama, Hiromi Nochi
doaj +1 more source