Results 31 to 40 of about 10,923 (183)
Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation. [PDF]
PLoS ONE, 2011 BACKGROUND: Recent research supports that aggregation of islet amyloid polypeptide (IAPP) leads to cell death and this makes islet amyloid a plausible cause for the reduction of beta cell mass, demonstrated in patients with type 2 diabetes.
Sebastian Wolfgang Schultz +2 more
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Amyloid-Mediated Mechanisms of Membrane Disruption
Biophysica, 2021 Protein aggregation and amyloid formation are pathogenic events underlying the development of an increasingly large number of human diseases named “proteinopathies”.
Michele F. M. Sciacca +2 more
doaj +1 more source
Scientific Reports, 2017 Type 2 diabetes is characterized by insulin tolerance in target cells followed by a reduction of pancreatic β-cell mass. Islet amyloid polypeptide oligomeric assemblies were shown to contribute to β-cell apoptosis by forming discrete pores that ...
Yaron Bram +4 more
doaj +1 more source
Journal of Diabetes Investigation, 2021 Aims/Introduction Islets have microvessels that might develop pathological alterations similar to microangiopathy in type 2 diabetes patients. It remains unclear, however, whether the changes correlate with endocrine cell deficits or whether the presence
Kazuhisa Takahashi +7 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2021 Islet amyloid polypeptide (IAPP) is a neuroendocrine hormone from pancreatic β-cells. Misfolded, aggregated IAPP is believed to be toxic to islet cells and amyloid deposits in the pancreas are pathological hallmarks of type 2 diabetes.
Madison Q. Ferguson, Maria C. DeRosa
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji +2 more
wiley +1 more source
Quantitative Studies of Amyloid in the Islets of Langerhans [PDF]
Upsala Journal of Medical Sciences, 1972 AbstractThe relationship between the degree of amyloidosis in pancreatic islet tissue and the frequency of islets containing amyloid was studied in an autopsy material. A very strong positive correlation was found between these two variables in both the head and the tail of the pancreas.
openaire +2 more sources
Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis [PDF]
Journal of Biological Chemistry, 2015 Deposition of β cell toxic islet amyloid is a cardinal finding in type 2 diabetes. In addition to the main amyloid component islet amyloid polypeptide (IAPP), heparan sulfate proteoglycan is constantly present in the amyloid deposit. Heparan sulfate (HS) side chains bind to IAPP, inducing conformational changes of the IAPP structure and an acceleration
Marie E, Oskarsson +5 more
openaire +2 more sources
Equine Veterinary Journal, EarlyView.Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee +4 more
wiley +1 more source
Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin
Nature Communications, 2022 Integrated kinetic and structural investigations reveal that the ubiquitous co-chaperonin prefoldin interacts with its coiled-coil helices on the islet amyloid polypeptide fibril surface and fibril ends to inhibit fibril elongation and secondary ...
Ricarda Törner +10 more
doaj +1 more source