Results 11 to 20 of about 6,150 (181)

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology [PDF]

Journal of Diabetes Research, 2016
The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose homeostasis but aggregates to form islet amyloid in type-2 diabetes. Islet amyloid formation contributes to β-cell dysfunction and death in the disease and to the failure of ...
Rehana Akter, Ping Cao, Harris Noor, Zachary Ridgway, Ling-Hsien Tu, Hui Wang, Amy G. Wong, Xiaoxue Zhang, Andisheh Abedini, Ann Marie Schmidt, Daniel P. Raleigh   +10 more
doaj   +5 more sources

Degradation of islet amyloid polypeptide by neprilysin [PDF]

Diabetologia, 2012
A progressive loss of pancreatic beta cell function, a decrease in beta cell mass and accumulation of islet amyloid is characteristic of type 2 diabetes mellitus. The main constituent of islet amyloid is islet amyloid polypeptide (IAPP). In this study, we examined the ability of the peptidase neprilysin to cleave IAPP and prevent human IAPP-induced ...
H, Guan, K M, Chow, R, Shah, C J, Rhodes, L B, Hersh   +4 more
openaire   +2 more sources

Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin

Nature Communications, 2022
Integrated kinetic and structural investigations reveal that the ubiquitous co-chaperonin prefoldin interacts with its coiled-coil helices on the islet amyloid polypeptide fibril surface and fibril ends to inhibit fibril elongation and secondary ...
Ricarda Törner, Tatsiana Kupreichyk, Lothar Gremer, Elisa Colas Debled, Daphna Fenel, Sarah Schemmert, Pierre Gans, Dieter Willbold, Guy Schoehn, Wolfgang Hoyer, Jerome Boisbouvier   +10 more
doaj   +1 more source

High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus. [PDF]

PLoS ONE, 2014
Aims/hypothesisIslet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid ...
Johan F Paulsson, Johnny Ludvigsson, Annelie Carlsson, Rosaura Casas, Gun Forsander, Sten A Ivarsson, Ingrid Kockum, Åke Lernmark, Claude Marcus, Bengt Lindblad, Gunilla T Westermark   +10 more
doaj   +1 more source

Decreased islet amyloid polypeptide staining in the islets of insulinoma patients. [PDF]

Islets
Islet amyloid polypeptide (IAPP) is a factor that regulates food intake and is secreted from both pancreatic islets and insulinoma cells. Here, we aimed to evaluate IAPP immunohistochemically in islets or insulinoma cells in association with clinical characteristics.
Ishibashi C, Yoneda S, Fujita Y, Fujita S, Mitsushio K, Ozawa H, Baden MY, Nammo T, Kozawa J, Eguchi H, Shimomura I.   +10 more
europepmc   +3 more sources

Type 2 diabetes mellitus as a prion disease (literature review)

Известия высших учебных заведений. Поволжский регион: Медицинские науки, 2022
Type 2 diabetes mellitus (T2DM) is the most common endocrine disease characterized by impaired insulin, hyperglycemia and chronic insulin resistance due to dysfunction and loss of β-cells of the islets of Largenhans.
A.S. Filimonova, D.S. Mar'evskaya, T.V. Ulanova, L.N. Komarova   +3 more
doaj   +1 more source

IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

Nature Communications, 2019
Type 2 diabetes is associated with islet amyloid deposits derived from islet amyloid polypeptide (IAPP) expressed by β-cells. Here the authors show that IAPP misfolded protein stress induces the hypoxia inducible factor 1 alpha injury repair pathway and ...
Chiara Montemurro, Hiroshi Nomoto, Lina Pei, Vishal S. Parekh, Kenny E. Vongbunyong, Suryakiran Vadrevu, Tatyana Gurlo, Alexandra E. Butler, Rohan Subramaniam, Eleni Ritou, Orian S. Shirihai, Leslie S. Satin, Peter C. Butler, Slavica Tudzarova   +13 more
doaj   +1 more source

Active Immunization Against hIAPP Oligomers Ameliorates the Diabetes- Associated Phenotype in a Transgenic Mice Model

Scientific Reports, 2017
Type 2 diabetes is characterized by insulin tolerance in target cells followed by a reduction of pancreatic β-cell mass. Islet amyloid polypeptide oligomeric assemblies were shown to contribute to β-cell apoptosis by forming discrete pores that ...
Yaron Bram, Sivan Peled, Sayanti Brahmachari, Michael Harlev, Ehud Gazit   +4 more
doaj   +1 more source

General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. [PDF]

PLoS ONE, 2014
Islet amyloid polypeptide (IAPP or amylin) forms amyloid deposits in the islets of Langerhans; a process that is believed to contribute to the progression of type 2 diabetes and to the failure of islet transplants.
Hui Wang, Daniel P Raleigh
doaj   +1 more source

The Effect of Cholesterol on Membrane-Bound Islet Amyloid Polypeptide

Frontiers in Molecular Biosciences, 2021
Islet amyloid polypeptide (IAPP) is a proposed cause of the decreased beta-cell mass in patients with type-II diabetes. The molecular composition of the cell-membrane is important for regulating IAPP cytotoxicity and aggregation.
Mikkel Christensen, Mikkel Christensen, Mikkel Christensen, Nils A. Berglund, Birgit Schiøtt, Birgit Schiøtt   +5 more
doaj   +1 more source