Results 21 to 30 of about 6,150 (181)
Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis
Journal of Diabetes Research, 2015 Type II diabetes mellitus is associated with the deposition of fibrillar aggregates in pancreatic islets. The major protein component of islet amyloids is the glucomodulatory hormone islet amyloid polypeptide (IAPP).
Phuong Trang Nguyen +3 more
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Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation
Biomolecules, 2021 Amyloid-formation by the islet amyloid polypeptide (IAPP), produced by the β-cells in the human pancreas, has been associated with the development of type II diabetes mellitus (T2DM).
Sanduni Wasana Jayaweera +7 more
doaj +1 more source
Fibril Structure of Human Islet Amyloid Polypeptide [PDF]
Journal of Biological Chemistry, 2012 Misfolding and amyloid fibril formation by human islet amyloid polypeptide (hIAPP) are thought to be important in the pathogenesis of type 2 diabetes, but the structures of the misfolded forms remain poorly understood. Here we developed an approach that combines site-directed spin labeling with continuous wave and pulsed EPR to investigate local ...
Sahar, Bedrood +6 more
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Foldamer-mediated manipulation of a pre-amyloid toxin
Nature Communications, 2016 Intrinsically disordered proteins that form amyloid fibrils are hard to target with traditional therapeutic approaches. Here, the authors report on an oligoquinoline derivative that binds the human islet amyloid polypeptide, stabilising an alpha-helical ...
Sunil Kumar +5 more
doaj +1 more source
Data in Brief, 2016 Protein misfolding and aggregation are responsible for a large number of diseases called protein conformational diseases or disorders that include Alzheimer׳s disease, Huntington׳s diseases, Prion related encephalopathies and type-II diabetes (http://dx ...
Mohammed Inayathullah, Jayakumar Rajadas
doaj +1 more source
Neural Regeneration Research, 2021 Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions worldwide. Due to population ageing, the incidence of AD is increasing. AD patients develop cognitive decline and dementia, features for which is known, requiring permanent ...
Sofia Ferreira +3 more
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Amyloids in Site-Specific Autoimmune Reactions and Inflammatory Responses
Frontiers in Immunology, 2020 Amyloid deposition is a histological hallmark of common human disorders including Alzheimer's disease (AD) and type 2 diabetes. Although some reports highlight that amyloid fibrils might activate the innate immunity system via pattern recognition ...
Yan-Mei Huang +14 more
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Membrane permeabilization by Islet Amyloid Polypeptide [PDF]
Chemistry and Physics of Lipids, 2009 Membrane permeabilization by Islet Amyloid Polypeptide (IAPP) is suggested to be the main mechanism for IAPP-induced cytotoxicity and death of insulin-producing beta-cells in type 2 diabetes mellitus (T2DM). The insoluble fibrillar IAPP deposits (amyloid) present in the pancreas of most T2DM patients are not the primary suspects responsible for ...
openaire +4 more sources
Molecular Metabolism, 2017 Objectives: β-cell dysfunction and apoptosis associated with islet inflammation play a key role in the pathogenesis of type 2 diabetes (T2D). Growing evidence suggests that islet amyloid, formed by aggregation of human islet amyloid polypeptide (hIAPP ...
Queenie Hui +6 more
doaj +1 more source
Scientific Reports, 2021 Amyloid deposits in pancreatic islets, mainly formed by human islet amyloid polypeptide (hIAPP) aggregation, have been associated with loss of β-cell mass and function, and are a pathological hallmark of type 2 diabetes (T2D).
Sara de Pablo +9 more
doaj +1 more source