Results 11 to 20 of about 21,321 (228)

Calcinosis Cutis and Calciphylaxis in Autoimmune Connective Tissue Diseases

Vaccines, 2023
Calcinosis represents a severe complication of several autoimmune disorders. Soft-tissue calcifications have been classified into five major types: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis.
Ilaria Mormile, Francesca Mosella, Piergiorgio Turco, Filomena Napolitano, Amato de Paulis, Francesca Wanda Rossi   +5 more
doaj   +2 more sources

Complicated Catastrophic Calcium Gluconate Extravasation: Post-Surgical Graft Calcinosis Cutis. [PDF]

Clin Case Rep
ABSTRACT Extravasation is a rare but serious complication of intravenous injections, particularly with irritant or vesicant drugs, which can lead to significant tissue damage. In this case report, we describe a 14‐year‐old boy who developed calcinosis cutis due to extravasation of calcium gluconate, resulting in extensive tissue necrosis.
Abtahi-Naeini B, Rastegarnasab F, Kakavand N.   +2 more
europepmc   +2 more sources

Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis

Journal of Autoimmunity, 2023
Objectives: To elucidate mechanisms contributing to skeletal muscle calcinosis in patients with juvenile dermatomyositis. Methods: A well-characterized cohorts of JDM (n = 68), disease controls (polymyositis, n = 7; juvenile SLE, n = 10, and RNP ...
Bhargavi Duvvuri, L. Pachman, Payton Hermanson, Ting Wang, Richard L. Moore, Dennis Ding-Hwa Wang, Aaron Long, Gabrielle A Morgan, Stephen Doty, R. Tian, Y. Sancak, C. Lood   +11 more
semanticscholar   +1 more source

Management of Calcinosis Cutis in Rheumatic Diseases

Journal of Rheumatology, 2022
Calcinosis (hydroxyapatite and calcium phosphate crystal deposition) within the extracellular matrix of the dermis and subcutaneous tissue is a frequent manifestation of adult and pediatric systemic autoimmune rheumatic diseases, specifically systemic ...
Hadiya Elahmar, B. Feldman, S. Johnson
semanticscholar   +1 more source

Development of a computed tomography calcium scoring technique for assessing calcinosis distribution, pattern and burden in dermatomyositis.

Rheumatology, 2023
OBJECTIVES To utilize whole-body computed tomography (CT) imaging and calcium scoring techniques as tools for calcinosis assessment in a prospective cohort of patients with adult and juvenile dermatomyositis (DM and JDM, respectively).
Briana A Cervantes, Prateek C. Gowda, L. Rider, F. Miller, Marcus Y. Chen, Adam Schiffenbauer   +5 more
semanticscholar   +1 more source

CREST Syndrome in Systemic Sclerosis Patients – Is Dystrophic Calcinosis a Key Element to a Positive Diagnosis?

Journal of Inflammation Research, 2022
Introduction CREST syndrome is a clinical entity associated with systemic sclerosis, which meets at least three of the five clinical features: calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia.
Carmen Bobeica, E. Niculeț, Mihaela Craescu, Elena-Laura Parapiru, C. Musat, C. Dinu, I. Chiscop, L. Nechita, M. Debita, V. Stefanescu, I. Stefanopol, Alexandru Nechifor, A. Pelin, Gabriela Bălan, Silvia Chirobocea, C. Vasile, A. Tatu   +16 more
semanticscholar   +1 more source

Cumulative Disease Damage and Anti-PM/Scl Antibodies Are Associated with a Heavy Burden of Calcinosis in Systemic Sclerosis.

Rheumatology, 2022
OBJECTIVES Ectopic calcification (calcinosis) is a common complication of systemic sclerosis, but a subset of systemic sclerosis patients has a heavy burden of calcinosis. We examined whether there are unique risk factors for a heavy burden of calcinosis,
Carrie Richardson, J. Perin, S. Zeger, F. Wigley, L. Hummers, L. Casciola-Rosen, A. Rosen, Ami A. Shah   +7 more
semanticscholar   +1 more source

Distinct by Design: Unraveling the Unique Clinical and Transcriptomic Identity of Juvenile Scleromyositis Overlap Compared to Juvenile Systemic Sclerosis and Juvenile Dermatomyositis: Implications for Care and Pathogenesis. [PDF]

ACR Open Rheumatol
Objective To characterize clinical and transcriptomic differences in juvenile scleromyositis overlap (jOverlap) compared to juvenile systemic sclerosis (jSSc) and juvenile dermatomyositis (JDM), focusing on autoantibody profiles, organ involvement, treatment, and peripheral blood gene expression.
Robinson AD, Pain CE, Morgan GA, Sanyal A, Chaparala S, Pachman LM, Torok KS.   +6 more
europepmc   +2 more sources

Local, non-systemic, and minimally invasive therapies for calcinosis cutis: a systematic review

Archives of Dermatological Research, 2021
Calcinosis cutis is a deposition of calcium in the skin and subcutaneous tissue, often accompanied by pain, reduced mobility, and chronic infections. Limited evidence is available about the feasibility and efficacy of therapies alternative to systemic ...
Joanna Nowaczyk, Michał Zawistowski, P. Fiedor   +2 more
semanticscholar   +1 more source

Bisphosphonates for the Treatment of Calcinosis Cutis—A Retrospective Single-Center Study

Biomedicines, 2021
(1) Background: Calcinosis cutis is a frequent symptom of autoimmune connective tissue diseases leading to pain, transcutaneous expulsion of calcified material and bacterial superinfection.
Lilian Rauch, R. Hein, T. Biedermann, K. Eyerich, F. Lauffer   +4 more
semanticscholar   +1 more source