Results 41 to 50 of about 23,505 (252)

High proton pump inhibitor exposure increases risk of calcinosis in systemic sclerosis.

Rheumatology, 2020
OBJECTIVE To investigate the association between proton pump inhibitor (PPI) use and the presence and severity of calcinosis in SSc. METHODS We analysed data from two SSc cohorts from a single centre.
L. Host, C. Campochiaro, A. Afonso, S. Nihtyanova, C. Denton, V. Ong   +5 more
semanticscholar   +1 more source

Hyperphosphatemic familial tumoral calcinosis mimicking a cystic hemo-lymphangioma on MRI

Radiology Case Reports, 2022
A tumoral calcinosis is a rare benign pathology characterized by calcium deposits (calcium phosphate crystals) in the periarticular soft tissues, giving a truly pseudotumor appearance.
Salma El Houss, MD, Najlae LRhorfi, PhD, Zakia El Yousfi, MD, Siham EL Haddad, PhD, Latifa Chat, PhD, Nazik Allali, PhD, Naji Rguieg, MD, Najat Lamalmi, PhD   +7 more
doaj  

Critical Evaluation of Methods for the Identification of Aneugens

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun, Stephen D. Dertinger, Azeddine Elhajouji, Daniel J. Roberts, Jan van Benthem, Maik Schuler, Shambhu Roy, Alexandra Taraboletti, Connie L. Chen   +8 more
wiley   +1 more source

Surgical resection of symptomatic calcinosis in a patient with systemic sclerosis [PDF]

Revista Brasileira de Cirurgia Plástica, 2019
Introduction: Systemic sclerosis is a rare, autoimmune, progressive disease that affects connective tissues and internal organs by inflammation, which can cause calcinosis cutis.
Caio Pundek Garcia, Natalia Biancha Rendon, Carlo Mognon Mattiello, Flávia Cristina de Novaes Gerber, Jorge Bins-Ely   +4 more
doaj   +1 more source

The Prevalence and Severity of Pain in Patients With Systemic Sclerosis

The Journal of Dermatology, EarlyView.
ABSTRACT We investigated pain prevalence and severity in systemic sclerosis (SSc) and patient–physician perceptions. This was an internet‐based survey that compared perceptions of pain type, location, severity, associated factors between patients with SSc and physicians, and pain treatment prescription patterns in Japan in March 2023.
Sei‐ichiro Motegi, Mona Uchida‐Yamada, Yoshihito Shima, Taku Shimada, Haruka Ishii, Yoshito Ohya, Yasumasa Kanai   +6 more
wiley   +1 more source

Calcinosis in systemic sclerosis: prevalence, clinical picture, management, complications

Bolʹ, Sustavy, Pozvonočnik, 2019
This literature review summarizes current data on the epi­demiology, pathophysiology, diagnosis and treatment of calcinosis cutis in patients with systemic sclerosis (SSc).
Ye.D. Yehudina, I.Yu. Golovach
doaj   +1 more source

Dystrophic Calcinosis Cutis in Systemic Lupus Erythematosus

Cureus, 2020
Calcinosis cutis is a disorder of pathologic calcium deposition in the cutaneous and subcutaneous layers of skin. While common in dermatomyositis and scleroderma, calcinosis cutis less frequently occurs in systemic lupus erythematosus (SLE) and is ...
Ikechukwu Achebe, C. Mbachi, Jennifer C. Asotibe, Isaac K. O. Paintsil   +3 more
semanticscholar   +1 more source

RNA Analysis Enables Resolution and Reclassification of Reportedly Benign Synonymous Variants

Clinical Genetics, EarlyView.
Synonymous variants previously reported as benign present a diagnostic challenge in clinical exome sequencing. We show three cases where RNA studies demonstrated aberrant splicing and enabled reclassification of the variants. ABSTRACT Synonymous variants can significantly impact protein levels and function, particularly through alterations in RNA ...
Adina Fuchs, Inbar Kobal, Dov Popper, Shay Porat, Joshua I. Rosenbloom, Mordechai Slae, Shira Yanovsky Dagan, Vardiella Meiner, Vered Molho‐Pessach, Hagit Daum, Tamar Harel   +10 more
wiley   +1 more source

Idiopathic Calcinosis Cutis of the Hand

Plastic and Reconstructive Surgery, Global Open
Summary:. Calcinosis cutis is a disease process characterized by calcified lesions in the skin. Although there are five subtypes of calcinosis, idiopathic calcinosis cutis is a rare disease process with no clear etiology.
Shawhin R.K. Shahriari, MD, Tharani Murali, BS, Tegan N. Clarke, BA, Joseph F. Kuhn, MD, Shelly A. Stepenaskie, MD, Gregory L. Borah, MD, DMD   +5 more
doaj   +1 more source

Idiopathic Calcinosis Cutis over Elbow in a 12-Year Old Child

Case Reports in Orthopedics, 2013
Calcinosis cutis is an uncommon disorder caused by an abnormal deposit of calcium phosphate in the skin in various parts of the body. Four main types of calcinosis cutis have been recognized according to etiology: associated with localized or widespread ...
S. K. Venkatesh Gupta, Ramana Rao Balaga, Suman Kumar Banik   +2 more
doaj   +1 more source