Results 71 to 80 of about 6,912 (238)

A Rapidly Progressive Necrotic Ulcer in an Immunocompromised Patient

JEADV Clinical Practice, EarlyView.
R. Almutairi, H. Alajmi, M. Nouh, F. Alenezi, H. Al‐Sabah, A. Allafi   +5 more
wiley   +1 more source

Pharmacokinetics and Safety of Oral Pyrophosphate in Systemic Sclerosis Patients—A Pilot Study

ACR Open Rheumatology, Volume 7, Issue 4, April 2025.
Objective Calcinosis is a manifestation of systemic sclerosis with a severe negative impact on quality of life. Efforts to find a treatment for calcinosis have been hindered by our limited understanding of the underlying pathomechanism. We propose that extracellular pyrophosphate deficiency may have a causal role in the formation of these mineralized ...
Gergely Bodor, Márta Bocskai, Ágnes Dura, László Kovács, András Váradi, Eszter Kozák   +5 more
wiley   +1 more source

Calciphylaxis and its diagnosis: A review

Journal of Family Medicine and Primary Care, 2019
Calciphylaxis also known as Calcific uremic arteriolopathy (CUA), is a rare fatal complication usually associated with end-stage renal disease (ESRD). It is characterized by skin ulceration and necrosis leading to significant pain.
Deepak Baby, Meenakshi Upadhyay, M Derick Joseph, Swati Joshi Asopa, Basanta Kumar Choudhury, Jagadish Prasad Rajguru, Shivangi Gupta   +6 more
doaj   +1 more source

The Adverse Impact of Tyrosine Kinase Inhibitors on Wound Healing and Repair

International Wound Journal, Volume 22, Issue 4, April 2025.
ABSTRACT Tyrosine kinase inhibitors (TKIs) can treat various cancers, primarily through their antiangiogenic effects. However, as angiogenesis is crucial for successful wound healing, TKIs may adversely impact wound repair. This review analysed all 63 FDA‐approved TKIs and identified evidence for wound healing and repair implications in 24 agents.
William J. Nahm, Vincent Falanga
wiley   +1 more source

Calciphylaxis mimicking ecthyma gangrenosum

IDCases, 2019
Calciphylaxis is a rare cutaneous disease that may cause fatal complications in patients on long-term dialysis. Early diagnosis and proper management decrease complications.
Ranchana Tangkham, Siripan Sangmala, Kumpol Aiempanakit, Kanokphorn Chiratikarnwong, Sauvarat Auepemkiate   +4 more
doaj   +1 more source

Invalidisierende Kalziphylaxie (Calcific uraemic arteriolopathy) [PDF]

, 2018
Zusammenfassung: Ein 45-jähriger Patient mit langjährigem Diabetes mellitus Typ1 und diabetischer Nephropathie stellt sich vor. Nach zweijähriger Hämodialyse erfolgte im Alter von 35Jahren eine Nierentransplantation.
Göber, V., Neumann, A., Schenker, S., Schmidli, J.   +3 more
core  

Necrotizing Panniculitis as an Uncommon Manifestation of Acute Pancreatitis [PDF]

, 2017
Pancreatic panniculitis is a rare disorder affecting 2–3% of patients with pancreatic disease. The findings are characterized by tender, erythematous, subcutaneous nodules which may undergo spontaneous ulceration with discharge of brownish and viscous ...
Amaradio, Maria Domenica, Bellinvia, Salvatore, Bruno, Cosimo Marcello, Cantone, Damiano, Polosa, Riccardo, Pricoco, Gabriele Sebastiano   +5 more
core   +3 more sources

Hepatic Steatosis Aggravates Vascular Calcification via Extracellular Vesicle‐Mediated Osteochondrogenic Switch of Vascular Smooth Muscle Cells

Advanced Science, Volume 12, Issue 5, February 3, 2025.
Steatotic hepatocytes‐derived extracellular vesicles (SHep‐EVs) in the liver of mice with metabolic dysfunction‐associated fatty liver disease (MAFLD) can be transferred to vascular smooth muscle cells (VSMCs), exacerbating atherosclerosis and calcification by delivering Lgals3bp.
Zhao‐Lin Zeng, Zhi‐Bo Zhao, Qing Yuan, Shi‐Qi Yang, Zhen‐Xing Wang, Zuo Wang, Shi‐Yu Zeng, An‐Qi Li, Qian Chen, Guo‐Qiang Zhu, Xin‐Hua Xiao, Guang‐Hua Luo, Hai‐Yan Luo, Jiao‐Yang Li, Xu‐Yu Zu, Hui Xie, Jiang‐Hua Liu   +16 more
wiley   +1 more source

Elevated dietary magnesium during pregnancy and postnatal life prevents ectopic mineralization in Enpp1asj mice, a model for generalized arterial calcification of infancy. [PDF]

, 2017
Generalized arterial calcification of infancy (GACI) is an autosomal recessive disorder caused by mutations in the ENPP1 gene. It is characterized by mineralization of the arterial blood vessels, often diagnosed prenatally, and associated with death in ...
Kingman, Joshua, Li, Qiaoli, Uitto, Jouni   +2 more
core   +1 more source

Reoperation for persistent or recurrent secondary hyperparathyroidism [PDF]

, 2017
Background: Secondary hyperparathyroidism is a common acquired disorder seen in chronic renal failure. Its pathophysiology is mainly due to hyperphosphatemia and vitamin D deficiency and resistance.
Abruzzo, A., Buscemi, G., Buscemi, S., Damiano, G., Gioviale, M., Gulotta, L., LO MONTE, A., Lo Monte, G., Palumbo, V.   +8 more
core   +1 more source