Results 331 to 340 of about 152,832 (396)
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Current Medicinal Chemistry, 1999
The peptide calcitonin (CT) was initially discovered in 1962 as a novel hypocalcemic hormone. This hypocalcemic response was principally due to a potent inhibitory action of CT on osteoclast mediated bone resorption and it is this action which underlies its widespread clinical use for the treatment of bone disorders, including Paget's ...
Findlay, D., Sexton, P., Martin, T.
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The peptide calcitonin (CT) was initially discovered in 1962 as a novel hypocalcemic hormone. This hypocalcemic response was principally due to a potent inhibitory action of CT on osteoclast mediated bone resorption and it is this action which underlies its widespread clinical use for the treatment of bone disorders, including Paget's ...
Findlay, D., Sexton, P., Martin, T.
openaire +4 more sources
Rheumatic Disease Clinics of North America, 1997
Calcitonin is FDA approved for the treatment of postmenopausal osteoporosis but not for prevention. The preferred delivery system is nasal. Nasal calcitonin is safe and well tolerated. The vertebral fracture efficacy of calcitonin is less robust than the two approved bisphosphonates (alendronate and risedronate) but is similar to raloxifene in the ...
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Calcitonin is FDA approved for the treatment of postmenopausal osteoporosis but not for prevention. The preferred delivery system is nasal. Nasal calcitonin is safe and well tolerated. The vertebral fracture efficacy of calcitonin is less robust than the two approved bisphosphonates (alendronate and risedronate) but is similar to raloxifene in the ...
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Cephalalgia, 2020
Background Migraine has been associated with a dysfunctional activation of the trigeminovascular system. Calcitonin gene-related peptide, a neuropeptide released from the trigeminal nerve fibres, has an important role in the pathophysiology of migraine ...
E. Rubio-Beltrán +4 more
semanticscholar +1 more source
Background Migraine has been associated with a dysfunctional activation of the trigeminovascular system. Calcitonin gene-related peptide, a neuropeptide released from the trigeminal nerve fibres, has an important role in the pathophysiology of migraine ...
E. Rubio-Beltrán +4 more
semanticscholar +1 more source
Headache: The Journal of Head and Face Pain, 1986
SYNOPSISA group of 30 patients (12 M ‐ 18 F) suffering from migraine underwent salmon calcitonin therapy for a period of one month. All patients were treated at first for 30 days with vehicle administration in a daily i.m. injection, as a control. Calcitonin effectiveness was evaluated in terms of changes in frequency, intensity and duration of the ...
PATTI, Francesco +5 more
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SYNOPSISA group of 30 patients (12 M ‐ 18 F) suffering from migraine underwent salmon calcitonin therapy for a period of one month. All patients were treated at first for 30 days with vehicle administration in a daily i.m. injection, as a control. Calcitonin effectiveness was evaluated in terms of changes in frequency, intensity and duration of the ...
PATTI, Francesco +5 more
openaire +5 more sources
Headache, 2018
Objective – To briefly describe the history of and available data on anti‐calcitonin gene‐related peptide (CGRP) therapies for headache.
S. Tepper
exaly +2 more sources
Objective – To briefly describe the history of and available data on anti‐calcitonin gene‐related peptide (CGRP) therapies for headache.
S. Tepper
exaly +2 more sources
Calcitonin and the Peptides from the Calcitonin Gene
Clinical Orthopaedics and Related Research, 1987The alpha-calcitonin gene encodes a small family of peptides: calcitonin, katacalcin, and calcitonin gene-related peptide (CGRP). Calcitonin and katacalcin are produced from one precursor and CGRP from another. Calcitonin and katacalcin come mainly from the thyroid, while CGRP is present in both the thyroid and the central nervous system. Calcitonin is
P. J. R. Bevis +3 more
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Nature Communications, 2014 The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation.
Johannes Keller +2 more
exaly +2 more sources
Der Schmerz, 1990
A central antinociceptive effect of calcitonin has been well established in animal experiments. Owing to the lack of appropriate studies, however, a final judgement cannot be made regarding the value of calcitonin in pain therapy. Positive clinical experiences have been reported in the following cases.
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A central antinociceptive effect of calcitonin has been well established in animal experiments. Owing to the lack of appropriate studies, however, a final judgement cannot be made regarding the value of calcitonin in pain therapy. Positive clinical experiences have been reported in the following cases.
openaire +3 more sources
Clinical Reviews in Bone and Mineral Metabolism, 2005
Calcitonin is a 32-amino acid polypeptide secreted by the parafollicular cells of the thyroid. Effects on bone include inhibition of osteoclasts, thus preventing bone resorption, as well as increased renal calcium excretion. Salmon calcitonin is often used therapeutically because it is more potent and has a longer duration of action compared with human
Julienne K. Kirk, Charley A. Hepfinger
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Calcitonin is a 32-amino acid polypeptide secreted by the parafollicular cells of the thyroid. Effects on bone include inhibition of osteoclasts, thus preventing bone resorption, as well as increased renal calcium excretion. Salmon calcitonin is often used therapeutically because it is more potent and has a longer duration of action compared with human
Julienne K. Kirk, Charley A. Hepfinger
openaire +2 more sources
2003
Mini Review ; There is yet much to learn about the actions and role of CT. It will be important to better understand die physicochemistry of CT-CTR interaction, and the pharmacokinetics of CT, so that small molecule CT-mimetics and more potent, differently delivered, longer acting forms of the molecule can be designed to control bone resorption and ...
Findlay, D., Sexton, P.
openaire +3 more sources
Mini Review ; There is yet much to learn about the actions and role of CT. It will be important to better understand die physicochemistry of CT-CTR interaction, and the pharmacokinetics of CT, so that small molecule CT-mimetics and more potent, differently delivered, longer acting forms of the molecule can be designed to control bone resorption and ...
Findlay, D., Sexton, P.
openaire +3 more sources