Results 51 to 60 of about 3,058,950 (364)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa   +3 more
wiley   +1 more source

Three-Dimensional Model of Sub-Plasmalemmal Ca2+ Microdomains Evoked by T Cell Receptor/CD3 Complex Stimulation

open access: yesFrontiers in Molecular Biosciences, 2022
Ca2+ signalling plays an essential role in T cell activation, which is a key step to start an adaptive immune response. During the transition from a quiescent to a fully activated state, Ca2+ microdomains of reduced spatial and temporal extents develop ...
Diana Gil   +3 more
doaj   +1 more source

Involvement of Protein Kinase C and Protein Kinase A in the Enhancement of L-type Calcium Current by GABA\u3csub\u3eB\u3c/sub\u3e Receptor Activation in Neonatal Hippocampus [PDF]

open access: yes, 2011
In the early neonatal period activation of GABAB receptors attenuates calcium current through N-type calcium channels while enhancing current through L-type calcium channels in rat hippocampal neurons.
Bray, Jennifer Grace, Mynlieff, Michelle
core   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda   +15 more
wiley   +1 more source

Study on Calcified Alkali Leaching of Vanadium-Extracted Tailings and Preparation of Barium Orthovanadate

open access: yesNanomaterials
While vanadium-extracted tailings contain valuable components, their utilization is difficult due to their high sodium content. In this work, a new oxygen-pressure calcification and alkaline leaching strategy to achieve barium orthovanadate vanadium ...
Jinwei Qu, Yiqiu Wang, Xinyu Hao, Na Ma
doaj   +1 more source

Vascular Calcification and Stone Disease: A New Look towards the Mechanism

open access: yesJournal of Cardiovascular Development and Disease, 2015
Calcium phosphate (CaP) crystals are formed in pathological calcification as well as during stone formation. Although there are several theories as to how these crystals can develop through the combined interactions of biochemical and biophysical factors,
Allen J. Yiu   +3 more
doaj   +1 more source

Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells [PDF]

open access: yes, 1990
In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated ...
Chegini, S.   +3 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca2+-dependent inactivation

open access: yesNature Communications, 2016
Timothy Syndrome (TS) is a multisystem disorder caused by two mutations leading to dysfunction of the CaV1.2 channel. Here, Dick et al. uncover a major and mechanistically divergent effect of both mutations on Ca2+/calmodulin-dependent inactivation of ...
Ivy E. Dick   +3 more
doaj   +1 more source

Calcium Phosphate Cement Leakage During Balloon Kyphoplasty Causing Incomplete Paraplegia: Case Report and Review of the Literature

open access: yesJournal of Orthopedic and Spine Trauma, 2016
Introduction: Bone cement leakage is the most common, however, it can have potentially disastrous complications during vertebroplasty and balloon kyphoplasty (BK).
Papaioannou Ioannis   +2 more
doaj   +1 more source

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