Results 111 to 120 of about 212,769 (372)

Flexible metro network architecture based on wavelength blockers and coherent transmission [PDF]

European Conference on Optical Communication (ECOC) 2019, 2020
A flexible semi-filterless architecture for metro DWDM networks with ring- or horseshoe topologies is presented. ROADM nodes are based on wavelength blockers. Coherent transmission enables filterless channel selection. Critical parameters are determined and a 4-span, 160-km horseshoe with 100Gbit/s DP-QPSK and 200Gbit/s DP-16QAM is demonstrated.
arxiv  

Cellular bases for human atrial fibrillation [PDF]

, 2008
Atrial fibrillation (AF) causes substantial morbidity and mortality. It may be triggered and sustained by either reentrant or nonreentrant electrical activity. Human atrial cellular refractory period is shortened in chronic AF, likely aiding reentry. The
Andrew C. Rankin, Antony J. Workman, Balana, Bosch, Brandt, Brundel, Brundel, Cha, Cha, Cha, Cheng, Christ, Dobrev, Dobrev, Dobrev, Ehrlich, Fatkin, Gaborit, Grammer, Greiser, Hove-Madsen, Kathleen A. Kane, Klein, Kneller, Koumi, Koumi, Le Grand, Mansourati, Marshall, Marshall, Ouadid, Pandit, Pau, Pau, Raine, Redpath, Schotten, Schreieck, Schreieck, Skasa, Van Wagoner, Van Wagoner, Vest, Voigt, Wijffels, Wit, Workman, Workman, Workman, Workman, Wu, Zhang   +51 more
core   +2 more sources

Gingival hyperplasia induced by Nifedipine: case report [PDF]

, 2002
Nifedipine, a calcium channel blocker, is commonly used in the treatment of cardiovascular disorders. In this paper a case report is presented which describes a patient medicated with Nifedipine for angina pectoris and arterial hypertension, who ...
Pićurić Ivana, Đurić Milanko
core   +1 more source

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Pharmacological, Pharmacokinetic, and Clinical Properties of Benidipine Hydrochloride, a Novel, Long-Acting Calcium Channel Blocker

Journal of Pharmacological Sciences, 2006
.: Benidipine is a dihydropyridine-derived calcium channel blocker developed in Japan, with several unique mechanisms of action, that is, triple calcium channels (L, N, and T) blocking action with a membrane approach.
Kozo Yao, Ken Nagashima, Hiroyuki Miki
doaj  

Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes

FEBS Open Bio, EarlyView.
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya, Ksenia V. Sergeeva, Boris S. Shenkman, Timur M. Mirzoev   +3 more
wiley   +1 more source

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

FEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang   +5 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Theory and experiment reveal unexpected calcium profiles in one-dimensional systems [PDF]

arXiv, 2013
Calcium is an ubiquitous second messenger that triggers a plethora of key physiological responses. The events are initiated in micro- or nano-sized compartments and determined by the complex interactions with calcium-binding proteins and mechanisms of calcium clearance. Local calcium increases in the vicinity of single channels represent an essentially
arxiv  

Discrete stochastic modeling of calcium channel dynamics [PDF]

, 1999
We propose a simple discrete stochastic model for calcium dynamics in living cells. Specifically, the calcium concentration distribution is assumed to give rise to a set of probabilities for the opening/closing of channels which release calcium thereby changing those probabilities.
arxiv   +1 more source