A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study
Advanced Biology, EarlyView.Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers +10 more
wiley +1 more source
A Modern View on the Treatment for Acute Calcium Channel Blocker Poisoning
Неотложная медицинская помощьBACKGROUND. At the beginning of the 21st century, the structure of acute exotoxicoses changed, in particular, an increase in poisoning by drugs that mainly affect the cardiovascular system, including calcium channel blockers, was noted.
A. Yu. Simonova +4 more
doaj +1 more source
Intravenous Dantrolene Does Not Exhibit Calcium Channel Blocking Effects on the Cardiac Conduction System in Humans [PDF]
, 1991 M. Kentsch +3 more
openalex +1 more source
Intestinal Ischemia-Reperfusion Injury and Calcium Channel Blockers: Getting to the Core of the Problem [PDF]
, 2020 John Mackay Søfteland, Mihai Oltean
openalex +1 more source
Advanced Biology, EarlyView.In this study, Seaman et al. develop a co‐culture assay to examine interactions between prostate cancer cells and mineralized osteoblasts in a microfluidic platform. The authors collect conditioned media from static or flow‐stimulated osteocytes and demonstrate that mechanical loading of osteocytes regulates the growth of prostate cancer cells and ...
Kimberly Seaman +5 more
wiley +1 more source
Ventricular Action Potential Adaptation to Regular Exercise: Role of β-adrenergic and K\u3csub\u3eATP\u3c/sub\u3e Channel Function [PDF]
, 2017 Regular exercise training is known to affect the action potential duration (APD) and improve heart function, but involvement of β-adrenergic receptor (β-AR) subtypes and/or the ATP-sensitive K+ (KATP) channel is unknown.
Fitts, Robert H., Wang, Xinrui
core +1 more source
Osteogenic Effects of Ion Released from Biodegradable Metallic Magnesium and Calcium Coating
Advanced Biology, EarlyView.This study explores how magnesium–calcium coatings on titanium promote osteogenesis by releasing ions and elevating pH during degradation. Using osteoblast‐like cells, the research demonstrates that both ion release and pH changes contribute to cell proliferation, differentiation, and mineralization, offering new insights into the design of bioactive ...
Risa Miyake +4 more
wiley +1 more source
Combination therapy of hypertension in the elderly: a subgroup analysis of the Combination of OLMesartan and a calcium channel blocker or diuretic in Japanese elderly hypertensive patients trial [PDF]
, 2014 Toshio Ogihara +9 more
openalex +1 more source