Calcium Channel Blocker Overdose [PDF]
Journal of education & teaching in emergency medicineEmergency medicine residents and medical students on emergency medicine rotation.Calcium channel blocker (CCB) overdoses can be severe with potentially serious adverse outcomes. CCBs work by blocking the calcium channels on smooth and cardiac muscle tissue. At low dose ranges, dihydropyridine CCBs (such as nifedipine, amlodipine, and nicardipine) block
Andrusaitis, MD, MS, Jessica G. +1 more
openaire +4 more sources
Comparison of First-Line Dual Combination Treatments in Hypertension: Real-World Evidence from Multinational Heterogeneous Cohorts. [PDF]
, 2020 Background and objectives: 2018 ESC/ESH Hypertension guideline recommends 2-drug combination as initial anti-hypertensive therapy. However, real-world evidence for effectiveness of recommended regimens remains limited.
Cho, Jaehyeong +10 more
core +2 more sources
Medicine, 2003 Overdose of calcium channel blockers is potentially lethal. Verapamil and diltiazem are much more dangerous than dihydropyridines. Hypotension with (verapamil and diltiazem) or without (dihydropyridines) heart block and bradycardia are the most important features.
Buckley, Nicholas +2 more
openaire +2 more sources
Use of drug therapy in the management of symptomatic ureteric stones in hospitalized adults (SUSPEND), a multicentre, placebo-controlled, randomized trial of a calcium-channel blocker (nifedipine) and an α-blocker (tamsulosin) : study protocol for a randomized controlled trial [PDF]
, 2014 Peer reviewedPublisher ...
Anson, Ken +12 more
core +2 more sources
Oestrogen as a calcium channel blocker [PDF]
European Heart Journal, 1996 This paper reviews the evidence for calcium-antagonist properties of oestrogen which may offer long-term protective effects on the cardiovascular system in postmenopausal women. Oestrogen has already been shown to have a beneficial effect on cholesterol metabolism and deposition, thereby inhibiting the formation of atherosclerotic plaque and coronary ...
P, Collins, C M, Beale, G M, Rosano
openaire +2 more sources
Calcium Channel Blockers and Hypertension
Journal of Cardiovascular Pharmacology and Therapeutics, 2014 Effective treatment of high blood pressure (BP) represents a key strategy for reducing the burden of hypertension-related cardiovascular and renal diseases. In spite of these well-established concepts, hypertension remains poorly controlled worldwide.
TOCCI, GIULIANO +6 more
openaire +3 more sources
A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes [PDF]
, 2005 We investigated the role of small-conductance calcium-activated potassium (SK) and intermediate-conductance calcium-activated potassium channels in modulating sensory transmission from peripheral afferents into the rat spinal cord.
Bahia, PK +7 more
core +1 more source
Strategies for studying permeation at voltage-gated ion channels [PDF]
, 1991 Voltage-dependent ion channels are presently thought to consist of several distinct functional regions: (a) activation gates, (b) inactivation gates, and permeation pathways.
Lester, Henry A.
core +1 more source
Chronic beta-adrenoceptor blockade and human atrial cell electrophysiology: evidence of pharmacological remodelling [PDF]
, 2003 <b>Objective:</b> Chronic beta-adrenoceptor antagonist (β-blocker) treatment reduces the incidence of reversion to AF in patients, possibly via an adaptive myocardial response.
Kane, K.A. +4 more
core +1 more source
Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential [PDF]
, 2008 Background Factors that regulate intracellular calcium concentration are known to play a critical role in brain function and neural development, including neural plasticity and neurogenesis.
Jun Ming Wang +74 more
core +2 more sources