Results 31 to 40 of about 1,855,990 (303)

Evaluation of prescription pattern of anti - Hypertensive drugs in Urban population of Hyderabad

MRIMS Journal of Health Sciences, 2014
Knowledge of existing prescription patterns in the treatment of hypertension can provide useful information for improving clinical practice in this field.
M Jamuna Rani, G Jyothsna, Rohit Singh
doaj   +1 more source

Activation of PAC1 receptors in rat cerebellar granule cells stimulates both calcium mobilization from intracellular stores and calcium influx through N-type calcium channels

Frontiers in Endocrinology, 2013
High concentrations of pituitary adenylate cyclase-activating polypeptide (PACAP) and a high density of PACAP binding sites have been detected in the developing rat cerebellum.
Magali eBasille-Dugay, Magali eBasille-Dugay, Magali eBasille-Dugay, Magali eBasille-Dugay, Hubert eVaudry, Hubert eVaudry, Hubert eVaudry, Hubert eVaudry, Alain eFournier, Alain eFournier, Bruno J. Gonzalez, Bruno J. Gonzalez, David eVaudry, David eVaudry, David eVaudry, David eVaudry   +15 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Bilateral blindness secondary to optic nerve ischemia from severe amlodipine overdose: a case report

Journal of Medical Case Reports, 2017
Background Calcium channel blockers are commonly prescribed medications; calcium channel blocker overdose is becoming increasingly prevalent. The typical presentation of a calcium channel blocker overdose is hypotension and decreased level of ...
Raymond Kao, Yves Landry, Genevieve Chick, Andrew Leung   +3 more
doaj   +1 more source

R-type calcium channels are crucial for semaphorin 3A-induced DRG axon growth cone collapse. [PDF]

PLoS ONE, 2014
Semaphorin 3A (Sema3A) is a secreted protein involved in axon path-finding during nervous system development. Calcium signaling plays an important role during axonal growth in response to different guidance cues; however it remains unclear whether this ...
Rimantas Treinys, Andrius Kaselis, Emmanuel Jover, Dominique Bagnard, Saulius Šatkauskas   +4 more
doaj   +1 more source

Life threatening hypokalaemia during treatment of severe diltiazem overdose with high dose insulin euglycemic therapy: a case report

Toxicology Communications, 2021
Calcium channel blockers (CCB) overdose can result in cardiogenic shock and that high dose insulin euglycaemic therapy (HIET) is increasingly used to treat CCB poisoning.
Andrew Kozman, Kerry Hoggett, Jessamine Soderstrom   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The relationship between apamin binding and channel block in KCa2 potassium channels. [PDF]

, 2013
Small conductance calcium-activated potassium channels (KCa2.1,2.2,2.3) are widely distributed throughout the body and are involved in diverse physiological processes including the regulation of neuronal firing and smooth muscle contraction.
Jenkinson, DH, Moss, GWJ, Benton, DCH, Garbarg, M   +3 more
core  

Nitric Oxide and Small and Intermediate Calcium-Activated Potassium Channels Mediate the Vasodilation Induced by Apigenin in the Resistance Vessels of Hypertensive Rats

Molecules
Background: Apigenin (4′,5,7-trihydroxyflavone), a flavonoid with potential cardiovascular benefits, has unclear mechanisms of action. This study investigates its effects on vascular function in Spontaneously Hypertensive Rats (SHRs). Methods: Mesenteric
Lislaine Maria Klider, Maria Luiza Fidelis da Silva, Gustavo Ratti da Silva, João Ricardo Cray da Costa, Marcia Alessandra Arantes Marques, Emerson Luiz Botelho Lourenço, Francislaine Aparecida dos Reis Lívero, Jane Manfron, Arquimedes Gasparotto Junior   +8 more
doaj   +1 more source

Postoperative atrial fibrillation in paraesophageal hernia repair: can it be prevented?

Perioperative Medicine, 2021
Acute ischemic thromboembolic stroke is one of the most feared complications of atrial fibrillation (AF), and the risk increases with higher CHA2DS2-VASc scores.
Jennifer Mardini, Melanio Bruceta, William Parrella-O’Donnell, Kunal Karamchandani   +3 more
doaj   +1 more source