Results 1 to 10 of about 46,600 (231)

EFFECTS OF VERAPAMIL ON CHICKEN BIVENTER - CERVICIS MUSCLE [PDF]

Acta Medica Iranica, 1999
- Verapamil produces a sustained contraction in isolated biventer-cervicis muscle of chickens between 2-8 days old. From cumulative dose-response curves, ED50 of was calculated for this effect of verapamil.
F.Farokhy, M. Mahmoudian, S. Gerayesh-Nejad, A. R. Dehpour   +3 more
doaj   +3 more sources

Preliminary evaluation of the antiglycoxidant activity of verapamil using various in vitro and in silico biochemical/biophysical methods

Frontiers in Pharmacology, 2023
Introduction: Glycoxidative stress is essential for linking glucose disturbances and cardiovascular diseases. Unfortunately, contemporary antidiabetic drugs do not have an antiglycative effect but only lower blood glucose levels.
Miłosz Nesterowicz, Kamil Klaudiusz Lauko, Karolina Dańkowska, Daria Trocka, Małgorzata Żendzian-Piotrowska, Jerzy Robert Ładny, Anna Zalewska, Mateusz Maciejczyk   +7 more
doaj   +1 more source

Verapamil Blocks Scopolamine Enhancement Effect on Memory Consolidation in Passive Avoidance Task in Rats

Frontiers in Pharmacology, 2017
Our recent data have indicated that scopolamine, a non-selective muscarinic receptor antagonist, improves memory consolidation, in a passive avoidance task, tested in rats.
Verónica Giménez De Béjar, Verónica Giménez De Béjar, María Caballero Bleda, María Caballero Bleda, Natalija Popović, Natalija Popović, Miroljub Popović, Miroljub Popović   +7 more
doaj   +1 more source

INTERACTION OF VERAPAMIL AND LITHIUM AT THE NEUROMUSCULAR JUNCTION ON RAT ISOLATED MUSCLE-HEMIDIAPHRAGM [PDF]

Acta Medica Iranica, 1998
It has been reported that cither lithium or verapamil can potentiate the neuromuscular blocking activity of certain neuromuscular blockers. In the present investigation, possible interaction of verapamil with lithium has been described.
H. R. Sadeghipour, M. Mesbahian1 A.R. Dehpour   +1 more
doaj   +2 more sources

Arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells: comparison of vasorelaxant effects of verapamil and phentolamine

Acta Pharmaceutica Sinica B, 2017
Mitochondria are morphologically dynamic organelles which undergo fission and fusion processes. Our previous study found that arterial constriction was always accompanied by increased mitochondrial fission in smooth muscle cells, whereas inhibition of ...
Jing Jin, Xin Shen, Yu Tai, Shanliang Li, Mingyu Liu, Changlin Zhen, Xiuchen Xuan, Xiyue Zhang, Nan Hu, Xinzi Zhang, Deli Dong   +10 more
doaj   +1 more source

Clinical evaluation of nebulized verapamil in out‐patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease

The Clinical Respiratory Journal, 2022
Objective Chronic obstructive pulmonary disease (COPD) is associated with many health complications, including pulmonary hypertension (PH). Although oral calcium channel blockers have shown promising results in managing COPD‐induced PH, significant ...
Fanak Fahimi, Guitti Pourdowlat, Neda Behzadnia, Sahar Sadigh Mostofi, Aida Sefidani Forough, Omid Parto, Ayda Esmaeili   +6 more
doaj   +1 more source

Verapamil Alleviates Myocardial Ischemia/Reperfusion Injury by Attenuating Oxidative Stress via Activation of SIRT1

Frontiers in Pharmacology, 2022
Myocardial ischemia/reperfusion (I/R) injury is a potential complication of ischemic heart disease after recanalization. One of the primary reasons for I/R injury is the excessive accumulation of reactive oxygen species (ROS) in cardiomyocytes. Verapamil,
Mi Bao, Weiyi Huang, Weiyi Huang, Yang Zhao, Xinzhe Fang, Yanmei Zhang, Yanmei Zhang, Fenfei Gao, Fenfei Gao, Danmei Huang, Danmei Huang, Bin Wang, Bin Wang, Ganggang Shi, Ganggang Shi, Ganggang Shi   +15 more
doaj   +1 more source

Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway

Biomedicines
Tendinopathy is a prevalent condition in orthopedics patients, exerting a profound impact on tendon functionality. However, its underlying mechanism remains elusive and the efficacy of pharmacological interventions continues to be suboptimal.
Zengguang Wang, Zhenglin Dong, Yiming Li, Xin Jiao, Yihao Liu, Hanwen Chang, Yaokai Gan   +6 more
doaj   +1 more source

Verapamil and Alzheimer’s Disease: Past, Present, and Future

Frontiers in Pharmacology, 2020
Verapamil is a phenylalkylamine class calcium channel blocker that for half a century has been used for the treatment of cardiovascular diseases. Nowadays, verapamil is also considered as a drug option for the treatment of several neurological and ...
Natalija Popović, Natalija Popović, Nicanor Morales-Delgado, Nicanor Morales-Delgado, Nicanor Morales-Delgado, David Vidal Mena, Antonia Alonso, Antonia Alonso, María Pascual Martínez, María Caballero Bleda, María Caballero Bleda, Miroljub Popović, Miroljub Popović   +12 more
doaj   +1 more source

Verapamil chronicles: advances from cardiovascular to pancreatic β-cell protection

Frontiers in Pharmacology, 2023
Verapamil is a well-known drug used for treating angina and hypertension. Emerging data from current clinical trials suggest that this calcium channel blocker has a potential benefit for pancreatic β-cells through the elevation and sustenance of C ...
Hossein Arefanian, Lubaina Koti, Sardar Sindhu, Sardar Sindhu, Rasheed Ahmad, Ashraf Al Madhoun, Ashraf Al Madhoun, Fahd Al-Mulla   +7 more
doaj   +1 more source