Results 31 to 40 of about 46,600 (231)
Angewandte Chemie, EarlyView.Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey +13 more
wiley +2 more sources
Design And Evaluation Of Controlled Release Layered Matrix Tablets Of Paracetamol And Verapamil Hci. [PDF]
, 2009 Tablet matriks berlapis pelepasan terkawal parasetamol dan verapamil HCl dibangunkan menggunakan polimer hidrofilik dan hidrofobik, dan disediakan dengan kaedah pengranulan basah.
Rahamathullah, Shaikh
core +1 more source
Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides
Angewandte Chemie, EarlyView.Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi +8 more
wiley +2 more sources
Journal of Basic and Applied Zoology, 2016 Verapamil is a calcium channel blocker that has been widely used in the treatment of cardiovascular abnormalities, hypertension and angina pectoris. The present study investigates the effect of bee venom against verapamil embryotoxicity, bee venom (BV ...
Amin A. Seleem
doaj +1 more source
Na+/Ca2+ exchanger inhibitor SN-6 and verapamil reduce aldosterone synthase expression in adrenocortical carcinoma cell line NCI-H295R [PDF]
Jichu yixue yu linchuangObjective To investigate the effect of Na+/Ca2+ exchanger inhibitors SN-6 and calcium channel blocker verapamil on potassium-stimulated expression of aldosterone synthase in adrenocortical carcinoma cell line NCI-H295R(H295R).
WANG Yu, GAO Yinjie, REN Weidong, TONG Anli
doaj +1 more source
Anesthesiology Research and Practice, 2011 The aim of this experiment was to establish whether verapamil, nicardipine, and nitroglycerin have (1) infarct size-limiting effects and (2) antiarrhythmic effects in in vivo rabbit hearts during ischemia/reperfusion.
Hitoshi Yui +6 more
doaj +1 more source
PLoS ONE, 2014 In past years, the canonical Wnt/β-catenin signaling pathway has emerged as a critical regulator of cartilage development and homeostasis. FRZB, a soluble antagonist of Wnt signaling, has been studied in osteoarthritis (OA) animal models and OA patients ...
Akira Takamatsu +6 more
doaj +1 more source
Disparate effects of calcium channel blockers on pressure dependence of renin secretion and flow in the isolated perfused rat kidney [PDF]
, 1992 Using the model of isolated perfused rat kidneys this study was performed to investigate whether or not voltage-operated calcium channels are essentially involved in the pressure control of renin secretion from the kidneys. At a perfusion pressure of 100
Scholz, Holger, Kurtz, Armin
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Effect of Verapamil on Excitation-Contraction Coupling in Frog Single Twitch Muscle Fiber. II. Effect of Verapamil in High Concentration [PDF]
, 1981 The effects of verapamil in high concentration （0.5-5 mM） on electrical and mechanical responses, and on Ca uptake of fragmented sarcoplasmic reticulum （FSR） in frog skeletal muscle were examined and the following results were obtained. 1） Twitch tension
小原, 一男, 永井, 寅男
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić +4 more
wiley +1 more source