Results 51 to 60 of about 68,523 (237)

Verapamil and Alzheimer’s Disease: Past, Present, and Future

Frontiers in Pharmacology, 2020
Verapamil is a phenylalkylamine class calcium channel blocker that for half a century has been used for the treatment of cardiovascular diseases. Nowadays, verapamil is also considered as a drug option for the treatment of several neurological and ...
Natalija Popović, Natalija Popović, Nicanor Morales-Delgado, Nicanor Morales-Delgado, Nicanor Morales-Delgado, David Vidal Mena, Antonia Alonso, Antonia Alonso, María Pascual Martínez, María Caballero Bleda, María Caballero Bleda, Miroljub Popović, Miroljub Popović   +12 more
doaj   +1 more source

Verapamil chronicles: advances from cardiovascular to pancreatic β-cell protection

Frontiers in Pharmacology, 2023
Verapamil is a well-known drug used for treating angina and hypertension. Emerging data from current clinical trials suggest that this calcium channel blocker has a potential benefit for pancreatic β-cells through the elevation and sustenance of C ...
Hossein Arefanian, Lubaina Koti, Sardar Sindhu, Sardar Sindhu, Rasheed Ahmad, Ashraf Al Madhoun, Ashraf Al Madhoun, Fahd Al-Mulla   +7 more
doaj   +1 more source

Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues

Advanced Science, EarlyView.
Electrical stimulation (ESTIM) enhances vasculature formation in engineered human tissues. In 3D endothelial‐fibroblast constructs, conditioning with ESTIM promotes the formation of dense and highly branched networks that rapidly anastomose with mouse vasculature when implanted in vivo. Vessels formed under ESTIM are importantly functionally perfusable.
Katarzyna A. Grzelak, Ashley D. Westerfield, Vardhman Kumar, Kasturi Chakraborty, Navaneeth Krishna Rajeeva Pandian, Christopher S. Chen, Sangeeta N. Bhatia   +6 more
wiley   +1 more source

INTERACTION OF VERAPAMIL AND LITHIUM AT THE NEUROMUSCULAR JUNCTION ON RAT ISOLATED MUSCLE-HEMIDIAPHRAGM [PDF]

Acta Medica Iranica, 1998
It has been reported that cither lithium or verapamil can potentiate the neuromuscular blocking activity of certain neuromuscular blockers. In the present investigation, possible interaction of verapamil with lithium has been described.
H. R. Sadeghipour, M. Mesbahian1 A.R. Dehpour   +1 more
doaj   +2 more sources

Prolongation of AV nodal refractoriness by Ruta graveolens in isolated rat hearts [PDF]

, 2008
Objectives: To evaluate concentration-dependent effects of total extract of Rusta graveolens and its purified alkaloid fraction on the nodal basic and functional properties.
Golalipour, M.J., Khori, V., Marjani, A., Nayebpour, M., Semnani, S.   +4 more
core  

Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells [PDF]

, 2015
Tumor-initiating cells constitute a population within a tumor mass that shares properties with normal stem cells and is considered responsible for therapy failure in many cancers.
AMENDOLA, Donatella, Bearzi, Claudia, Bucci, Barbara, Camerlingo, Rosalba, CARICO, ELISABETTA, D'Agnano, Igea, DOMINICI, Carlo, Felsani, Armando, Guglielmi, Loredana, Iannetti, Ilaria, Leonetti, Carlo, MARESCA, GIOVANNA, MEGIORNI, Francesca, Mercanti, Delio, MILAN, MARIKA, Musa, Carla, Nardella, Marta, Pirozzi, Giuseppe, Porru, Manuela, Rizzi, Roberto, Sessa, Giuseppe   +20 more
core   +2 more sources

Not only P-glycoprotein: amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins [PDF]

, 2017
The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance ...
Assaraf, Yehuda G., Colotti, Gianni, Fazi, Francesco, Genovese, Ilaria, Ilari, Andrea   +4 more
core   +1 more source

Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway

Biomedicines
Tendinopathy is a prevalent condition in orthopedics patients, exerting a profound impact on tendon functionality. However, its underlying mechanism remains elusive and the efficacy of pharmacological interventions continues to be suboptimal.
Zengguang Wang, Zhenglin Dong, Yiming Li, Xin Jiao, Yihao Liu, Hanwen Chang, Yaokai Gan   +6 more
doaj   +1 more source

Light sheet microscopy with acoustic sample confinement [PDF]

, 2019
Contactless sample confinement would enable a whole host of new studies in developmental biology and neuroscience, in particular, when combined with long-term, wide-field optical imaging.
Cochran, Sandy, Cole, Katy L.H., Dholakia, Kishan, Lyons, David A., Nylk, Jonathan, Qiu, Yongqiang, Somorjai, Ildikó M.L., Spalding, Gabriel C., Wijesinghe, Philip, Yang, Zhengyi   +9 more
core   +7 more sources

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source