Results 61 to 70 of about 68,523 (237)

Cluster headache management and beyond [PDF]

, 2015
The therapeutic management of cluster headache is based on a very stable triad of drugs. Acute treatment has, in subcutaneous sumatriptan, its gold standard if compared to pure oxygen or indomethacin.
Martelletti, Paolo
core   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source

The Ca²⁺ Channel Blocker Verapamil Inhibits the In Vitro Activation and Function of T Lymphocytes: A 2022 Reappraisal

Pharmaceutics, 2022
Ca2+ channel blockers (CCBs) are commonly used to treat different cardiovascular conditions. These drugs disrupt the intracellular Ca2+ signaling network, inhibiting numerous cellular functions in different cells, including T lymphocytes. We explored the
José Ignacio Veytia-Bucheli, Den Alejandro Alvarado-Velázquez, Lourival Domingos Possani, Roberto González-Amaro, Yvonne Rosenstein   +4 more
doaj   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

Enhancing the cellular uptake of Py–Im polyamides through next-generation aryl turns [PDF]

, 2012
Pyrrole–imidazole (Py–Im) hairpin polyamides are a class of programmable, sequence-specific DNA binding oligomers capable of disrupting protein–DNA interactions and modulating gene expression in living cells.
Baird, Belitsky, Best, Bijsterbosch, Bradford, Chenoweth, Chenoweth, Chenoweth, Cleutjens, Cohen, Crowley, David C. Montgomery, Dervan, Dervan, Dickinson, Dose, D’Adamio, Edelson, Edwards, Gissot, Herman, Hesselberth, Hsu, Hsu, Jacobs, Johnson, Jordan L. Meier, Krutzik, Kwon, Magee, Mapp, Matsuda, Meijsing, Mrksich, Muzikar, Nickols, Nickols, Nickols, Nishijima, Ohtsukia, Olenyuk, Peter B. Dervan, Poulin-Kerstien, Reddy, Riegman, Rucker, Schmidt, Schultz, So, Swalley, Tsai, Van Dyke, Vaquerizas, Vichai, Yao   +54 more
core   +2 more sources

Radial Versus Femoral Access for Diagnostic Coronary Angiography: Insights From a Tertiary Academic Center in Johannesburg

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The radial artery is the preferred access for performing diagnostic coronary angiograms (DCA). However, data on the safety and efficacy of radial compared to femoral access in low‐ and middle‐income countries is limited. Aims This study aims to evaluate the safety and efficacy of radial versus femoral access in patients referred for
Khulasande Liso Ntaka, Dineo Mpanya, Umar G Adamu, Thomas Kalk, Nqoba Tsabedze   +4 more
wiley   +1 more source

Influence of verapamil on the pharmacokinetics of oridonin in rats

Pharmaceutical Biology, 2019
Context: Oridonin has been traditionally used in Chinese treatment of various cancers, but its poor bioavailability limits its therapeutic uses. Verapamil can enhance the absorption of some drugs with poor oral bioavailability.
Jing Liu, Ning Zhang, Na Li, Xiaocheng Fan, Ying Li   +4 more
doaj   +1 more source

Verapamil Inhibits Aspergillus Biofilm, but Antagonizes Voriconazole

Journal of Fungi, 2017
The paucity of effective antifungals against Aspergillus and increasing resistance, the recognition of the importance of Aspergillus biofilm in several clinical settings, and reports of verapamil—a calcium channel blocker—efficacy against Candida biofilm
Hasan Nazik, Varun Choudhary, David A. Stevens   +2 more
doaj   +1 more source