Results 71 to 80 of about 32,892 (194)

Radial Versus Femoral Access for Diagnostic Coronary Angiography: Insights From a Tertiary Academic Center in Johannesburg

Catheterization and Cardiovascular Interventions, Volume 108, Issue 2, Page 437-445, August 1, 2026.
ABSTRACT Background The radial artery is the preferred access for performing diagnostic coronary angiograms (DCA). However, data on the safety and efficacy of radial compared to femoral access in low‐ and middle‐income countries is limited. Aims This study aims to evaluate the safety and efficacy of radial versus femoral access in patients referred for
Khulasande Liso Ntaka, Dineo Mpanya, Umar G Adamu, Thomas Kalk, Nqoba Tsabedze   +4 more
wiley   +1 more source

STAT3 and Nrf2 pathways modulate the protective effect of verapamil on lung injury of diabetic rats

Endocrine Regulations, 2018
Objective. We aimed to assess the protective role of verapamil, L-type calcium channel blockers, against early lung damage in diabetic rats. Lung injury has recently been recognized as a consequent complication of diabetes mellitus. Hyperglycemia induces
Mohamed Mervat Z., Hafez Heba M., Mohamed Hanaa H., Zenhom Nagwa M.   +3 more
doaj   +1 more source

Impact of CYP2C19 and CYP3A4 Inhibitor Use on Clopidogrel Clinical Effectiveness in CYP2C19 Genotyped Patients Undergoing Percutaneous Coronary Intervention

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 531-541, August 2026.
CYP2C19 and CYP3A4 contribute to clopidogrel bioactivation. CYP2C19 no‐function alleles diminish clopidogrel's antiplatelet effects and clinical effectiveness. Coadministration of either a CYP2C19 or a CYP3A4 inhibitor may also reduce clopidogrel's antiplatelet effects and lead to phenoconversion in patients without a CYP2C19 no‐function allele (normal/
Danwei Shao, Jean G. Malavé, Joseph S. Rossi, Francesco Franchi, Ellen C. Keeley, Dominick J. Angiolillo, George A. Stouffer, Larisa H. Cavallari, Craig R. Lee   +8 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci   +10 more
wiley   +1 more source

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN   +11 more
wiley   +1 more source

Suppression of Gelatinase Activity in Human Peripheral Blood Mononuclear Cells by Verapamil [PDF]

Cell Journal, 2014
Objective: Gelatinases are a large group of proteolytic enzymes that belong to the matrix metalloproteinases (MMPs). MMPs are a broad family of peptidases, which proteolyse the extracellular matrix and have an important role in inflammation. Verapamil is
Fatemeh Hajighasemi, Neda Kakadezfuli
doaj  

Application of 2D‐Chromatography System for the Determination of Cosmetic Peptides in Skin Homogenates

Journal of Mass Spectrometry, Volume 61, Issue 8, August 2026.
ABSTRACT Peptides are increasingly employed as active ingredients in both therapeutic and cosmeceutical applications due to their high biological specificity, favorable safety profiles, and expanding market relevance. In topical formulations, peptide activity is typically confined to the skin, where widespread dermal proteases may significantly affect ...
Fosca Errante, Marco Pallecchi, Marta Menicatti, Lisa Giovannelli, Paolo Rovero, Gianluca Bartolucci   +5 more
wiley   +1 more source

Postoperative Nausea and Vomiting After Deep Sedation for Radiofrequency Catheter Ablation in Pediatric Patients

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
This retrospective study investigated the incidence of postoperative nausea and vomiting (PONV) in 70 pediatric radiofrequency catheter ablation procedures under deep sedation. PONV occurred in 17% of procedures, with a significantly higher incidence following left‐sided ablation. Importantly, the majority of PONV symptoms resolved spontaneously within
Yoshikatsu Takeda, Shuhei Fujita, Naoto Sakumura, Kazuyuki Ueno, Kengo Miyashita, Takeshi Futatani, Akio Chikata, Kazuo Usuda, Hidenori Iwasaki, Taichi Nakamura, Kunio Ohta, Taizo Wada   +11 more
wiley   +1 more source

Midterm Efficacy of SubcutAneous Implantable CardioVErter‐Defibrillator in ≤ 18 Year‐Old CHILDREN (SAVE CHILDREN‐II Registry)

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
S‐ICD therapy demonstrated favorable mid‐term safety and efficacy in pediatric patients, with durable sensing performance and a low incidence of device‐related infection. ABSTRACT Background The subcutaneous implantable cardioverter‐defibrillator (S‐ICD) avoids transvenous leads and is a promising option for sudden cardiac death (SCD) prevention in ...
Hitoshi Mori, Taisuke Nabeshima, Kota Nagaoka, Hideo Fukunaga, Hidemori Hayashi, Osamu Inaba, Yuhei Isonaga, So Asano, Junichi Nitta, Shigeo Watanabe, Sou Otsuki, Hiroshi Suzuki, Hidehira Fukaya, Jun Kishihara, Toshiyuki Chisaka, Takashi Higaki, Ayako Okada, Hideki Kobayashi, Takayuki Sekihara, Takafumi Oka, Seiichi Sato, Keisuke Yoshino, Hidekazu Kondo, Naohiko Takahashi, Ken Kato, Masaru Miura, Jun Maeda, Shuntaro Tamura, Kentaro Ikeda, Hiroko Goto, Takashi Murakami, Tsutomu Wada, Motoki Takamuro, Tsugutoshi Suzuki, Yuji Ishida, Shingo Sasaki, Takuro Nishimura, Masateru Takigawa, Tomomi Matsuura, Tomohiko Imamura, Satoshi Shizuta, Masato Fukunaga, Maiko Kuroda, Rintaro Hojo, Seiji Fukamizu, Hirohiko Suzuki, Yukihiko Yoshida, Itsuro Morishima, Kenji Kuraishi, Eiki Nishihara, Yoshihisa Naruse, Tomoyuki Sato, Yoshiyasu Aizawa, Kimitaka Nishizaki, Kentaro Nakamura, Norihito Nuruki, Masao Yoshinaga, Yukitoshi Ikeya, Yasuo Okumura, Shota Muraji, Yusuke Kondo, Makoto Nakano, Machiko Kito, Yasuya Inden, Satoshi Higuchi, Takahiko Kinjo, Kazuhisa Matsumoto, Masataka Narita, Wataru Sasaki, Tsukasa Naganuma, Daisuke Kawano, Naomichi Tanaka, Kei Matsumoto, Takuro Kojima, Yoshifumi Ikeda, Ritsushi Kato, Naokata Sumitomo   +76 more
wiley   +1 more source

Verapamil in diabetes

Indian Journal of Endocrinology and Metabolism, 2017
Resham Raj Poudel, Nisha Kusum Kafle
openaire   +3 more sources