Results 41 to 50 of about 46,600 (231)

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

CYP3A5 genetic variability influences sildenafil and metabolite in pulmonary hypertension

British Journal of Clinical Pharmacology, EarlyView.
Aim Interindividual variability in sildenafil response among pulmonary hypertension patients (PH) may be influenced by CYP3A5 polymorphisms. CYP3A5*3 allele reduces CYP3A5 activity and affects sildenafil metabolism. This study investigated the associations between CYP3A5 genotype and plasma concentrations of sildenafil and N‐desmethyl sildenafil, as ...
Pranisa Wongwien, Burabha Pussadhamma, Sirimas Kanjanawart, Thikhumporn Areesinpitak, Nontaya Nakkam, Chingching Foocharoen, Wichittra Tassaneeyakul, Suda Vannaprasaht   +7 more
wiley   +1 more source

verapamil

, 2012
OBJECTIVES: (R)-[(11)C]verapamil is widely used as a positron emission tomography (PET) tracer to evaluate P-glycoprotein (P-gp) functionality at the blood-brain barrier in man. A disadvantage of (R)-[(11)C]verapamil is the fact that its main metabolite,
Eriksson, P.A.J., Windhorst, Albert D., Lange, E.C.M. de, Lammertsma, Adriaan A, Syvänen, Stina,, de Lange, Elizabeth C M, Verbeek, J., Syvänen, Stina, de Lange, Elizabeth C, Windhorst, Albert D, Windhorst, A.D., Lammertsma, A.A., Verbeek, Joost, de Lange, E.C.M., Eriksson, Jonas,, Verbeek, Joost,, Schuit, R.C., Lammertsma, Adriaan A., Luurtsema, G., Syvanen, S., Schuit, Robert C., Eriksson, Jonas, Luurtsema, Gert, Schuit, Robert C   +23 more
core   +1 more source

Labeling Strategies for Monitoring Cytoskeleton Dynamics in Cultured Epithelial Cells

Cytoskeleton, EarlyView.
ABSTRACT Collective cell migration relies on coordinated cytoskeletal remodeling, yet the impact of live‐cell actin filament probes on these dynamics remains poorly characterized. Here, we systematically compared the performance and cellular effects of fluorogenic jasplakinolide‐based probes, SiR‐actin and SiR‐XActin, with the genetically encoded ...
Victoria Levario‐Diaz, Lakshmi Nyapathi‐Gopinath, Jonah Luka Voigt, Katharina Weber, Marlene Maager, Veselin Nasufovic, Elisabetta Ada Cavalcanti‐Adam   +6 more
wiley   +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

Therapeutic‐dose verapamil‐induced cardiogenic shock in an older patient: a case report

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Calcium channel blocker (CCB) toxicity most commonly follows deliberate overdose. However, severe toxicity at therapeutic doses may occur in susceptible individuals. Severe CCB toxicity often presents with clinical features of bradycardia, hypotension, hyperglycaemia, and lactic acidosis.
Christopher Thuring, Maria Carey, Timothy Webber, Biswadev Mitra   +3 more
wiley   +1 more source

Is DNA metabarcoding an option for formaldehyde‐preserved zooplankton time series?

Limnology and Oceanography: Methods, EarlyView.
Abstract The recovery of amplifiable DNA from formaldehyde‐fixed (FF) zooplankton samples has long been considered problematic, but advances in degraded‐DNA retrieval have renewed interest in FF samples. To access the information stored in long‐term zooplankton time series, we evaluated methods for extracting amplifiable DNA from community samples ...
Aitor Albaina, Anders Lanzén, Irati Miguel, Fernando Rendo, María Santos   +4 more
wiley   +1 more source

EFFECTS OF VERAPAMIL ON OVALBUMIN INDUCED CONTRACTION OF SENSITIZED GUINEA PIGS LUNG PARENCHYMAL TISSUES, IN VITRO

Pakistan Armed Forces Medical Journal, 2018
Calcium ions play an important patho-physiological role in allergic reactions. The release of mediators from mast cells, synthesis of some newly formed chemical mediators, airway smooth muscle contraction and nerve impulse conduction are all dependent ...
Syed Saud Hasan, Muhammad Yousuf Salat, Shaheen Sharaf Shah   +2 more
doaj   +2 more sources

Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity [PDF]

Bedaquiline is the cornerstone of a new regimen for the treatment of drug-resistant tuberculosis. However, its clinical use is threatened by the emergence of bedaquiline-resistant strains of Mycobacterium tuberculosis.
Cook, Gregory M., Chrisp, Michael T., Waller, Natalie J. E., McNeil, Matthew B., Edelstein, Paul H., Jowsey, William, Cheung, Chen-Yi, Troll, Mark, Fountain, Adam J., Ramakrishnan, Lalita, Waller, Natalie J.E., Cheung, Chen Yi, https://orcid.org/   +12 more
core   +1 more source

Verapamil-induced polymorphous ventricular tachycardia [PDF]

, 1985
A 31 year old woman who developed an atypical ventricular tachycardia after administration of intravenous verapamil for control of a recurrent supraventricular tachycardia is presented.
Joel Kupersmith, Winters, Stephen L., Kupersmith, Joel, Schweitzer, Paul, Gomes, Joseph A., Paul Schweitzer, Stephen L. Winters, Joseph A. Gomes   +7 more
core   +1 more source