Results 21 to 30 of about 32,892 (194)

Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.

PLoS ONE, 2014
In past years, the canonical Wnt/β-catenin signaling pathway has emerged as a critical regulator of cartilage development and homeostasis. FRZB, a soluble antagonist of Wnt signaling, has been studied in osteoarthritis (OA) animal models and OA patients ...
Akira Takamatsu, Bisei Ohkawara, Mikako Ito, Akio Masuda, Tadahiro Sakai, Naoki Ishiguro, Kinji Ohno   +6 more
doaj   +1 more source

Preliminary evaluation of the antiglycoxidant activity of verapamil using various in vitro and in silico biochemical/biophysical methods

Frontiers in Pharmacology, 2023
Introduction: Glycoxidative stress is essential for linking glucose disturbances and cardiovascular diseases. Unfortunately, contemporary antidiabetic drugs do not have an antiglycative effect but only lower blood glucose levels.
Miłosz Nesterowicz, Kamil Klaudiusz Lauko, Karolina Dańkowska, Daria Trocka, Małgorzata Żendzian-Piotrowska, Jerzy Robert Ładny, Anna Zalewska, Mateusz Maciejczyk   +7 more
doaj   +1 more source

Verapamil Blocks Scopolamine Enhancement Effect on Memory Consolidation in Passive Avoidance Task in Rats

Frontiers in Pharmacology, 2017
Our recent data have indicated that scopolamine, a non-selective muscarinic receptor antagonist, improves memory consolidation, in a passive avoidance task, tested in rats.
Verónica Giménez De Béjar, Verónica Giménez De Béjar, María Caballero Bleda, María Caballero Bleda, Natalija Popović, Natalija Popović, Miroljub Popović, Miroljub Popović   +7 more
doaj   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

EFFECTS OF VERAPAMIL ON CHICKEN BIVENTER - CERVICIS MUSCLE [PDF]

Acta Medica Iranica, 1999
- Verapamil produces a sustained contraction in isolated biventer-cervicis muscle of chickens between 2-8 days old. From cumulative dose-response curves, ED50 of was calculated for this effect of verapamil.
F.Farokhy, M. Mahmoudian, S. Gerayesh-Nejad, A. R. Dehpour   +3 more
doaj   +2 more sources

Recombinant Human Thrombopoietin Reduces the Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia

American Journal of Hematology, EarlyView.
ABSTRACT Chronic liver disease (CLD)‐related thrombocytopenia can limit the feasibility of invasive procedures. Recombinant human thrombopoietin (rhTPO) has demonstrated a favorable safety profile without hepatotoxicity. We evaluated the efficacy and safety of rhTPO in patients with CLD‐related thrombocytopenia who were undergoing elective invasive ...
Yifan Han, Ning Lin, Jinghang Xu, Sikui Wang, Jinglan Jin, Jia Shang, Yongning Xin, Youwen Tan, Dazhi Zhang, Jinlin Hou, Ping An, Wen Xie, Yujuan Guan, Qingfang Xiong, Hong Wu, Huiguo Ding, Yu Chen, Rongkuan Li, Zhili Wen, Mingqin Lu, Jinhui Yang, Zhongyin Zhou, Yongjian Zhou, Zujiang Yu, Kecan Lin, Wei Wang, Yan Huang, Yuemin Nan, Xinhua Luo, Rongshu Shi, Yi Kang, Tao Han, Shiyan Chen, Kai Wang, Yunfeng Shan, Jiaping Li, Pingguo Liu, Zheng Lu, Jun Chen, Zhen Liu, Liaoyun Zhang, Li Yang, Jifang Sheng, Zhan Zeng, Yanyan Yu, Xiaoyuan Xu   +45 more
wiley   +1 more source

Arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells: comparison of vasorelaxant effects of verapamil and phentolamine

Acta Pharmaceutica Sinica B, 2017
Mitochondria are morphologically dynamic organelles which undergo fission and fusion processes. Our previous study found that arterial constriction was always accompanied by increased mitochondrial fission in smooth muscle cells, whereas inhibition of ...
Jing Jin, Xin Shen, Yu Tai, Shanliang Li, Mingyu Liu, Changlin Zhen, Xiuchen Xuan, Xiyue Zhang, Nan Hu, Xinzi Zhang, Deli Dong   +10 more
doaj   +1 more source

Verapamil and Alzheimer’s Disease: Past, Present, and Future

Frontiers in Pharmacology, 2020
Verapamil is a phenylalkylamine class calcium channel blocker that for half a century has been used for the treatment of cardiovascular diseases. Nowadays, verapamil is also considered as a drug option for the treatment of several neurological and ...
Natalija Popović, Natalija Popović, Nicanor Morales-Delgado, Nicanor Morales-Delgado, Nicanor Morales-Delgado, David Vidal Mena, Antonia Alonso, Antonia Alonso, María Pascual Martínez, María Caballero Bleda, María Caballero Bleda, Miroljub Popović, Miroljub Popović   +12 more
doaj   +1 more source

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

INTERACTION OF VERAPAMIL AND LITHIUM AT THE NEUROMUSCULAR JUNCTION ON RAT ISOLATED MUSCLE-HEMIDIAPHRAGM [PDF]

Acta Medica Iranica, 1998
It has been reported that cither lithium or verapamil can potentiate the neuromuscular blocking activity of certain neuromuscular blockers. In the present investigation, possible interaction of verapamil with lithium has been described.
H. R. Sadeghipour, M. Mesbahian1 A.R. Dehpour   +1 more
doaj   +2 more sources