Results 51 to 60 of about 1,855,990 (303)

Trends in Calcium Channel Blocker Use in Patients with Heart Failure with Reduced Ejection Fraction and Comorbid Atrial Fibrillation

, 2021
BACKGROUND: Heart failure with reduced ejection fraction and atrial fibrillation commonly coexist. Most calcium channel blockers are not recommended in heart failure with reduced ejection fraction, but their use has been seldomly evaluated.
Barnes, Geoffrey D., Rubenfire, Melvyn, Krallman, Rachel, Montgomery, Daniel, Bumpus, Sherry, Cascino, Thomas, Garfein, Joshua, Cholack, George, Kline-Rogers, Eva   +8 more
core   +1 more source

Use of Antihypertensive Agents and Association With Risk of Adverse Outcomes in Chronic Kidney Disease: Focus on Angiotensin‐Converting Enzyme Inhibitors and Angiotensin Receptor Blockers

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Our objective was to determine patterns of antihypertensive agent use by stage of chronic kidney disease (CKD) and to evaluate the association between different classes of antihypertensive agents with nonrenal outcomes, especially in advanced ...
Elaine Ku, Charles E. McCulloch, Eric Vittinghoff, Feng Lin, Kirsten L. Johansen   +4 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist [PDF]

, 2013
Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Jackson, Edwin K., Blessing, CP, Tammy Liu, Liu, Tammy, Liu, T, Christopher P Blessing, Jackson Edwin K., Liu Tammy, Gul, R, Pulakat, Lakshmi, Pulakat, L, Murat Bastepe, Blessing, Christopher P., Edwin K Jackson, Catherine E Erickson, Rukhsana Gul, Bastepe Murat, Lakshmi Pulakat, Andresen Bradley T., Nguyen, J, Pulakat Lakshmi, Gul, Rukhsana, Andresen, Bradley T., Erickson, CE, Blessing Christopher P., Holowka, David, Nguyen Jenny, Bastepe, Murat, Jackson, EK, Andresen, BT, Gul Rukhsana, Jenny Nguyen, Erickson Catherine E., Bastepe, M, Erickson, Catherine E., Nguyen, Jenny, Bradley T Andresen   +36 more
core   +2 more sources

Calcium-channel blockers and anaesthesia [PDF]

Canadian Journal of Anaesthesia, 1991
Verapamil was the first calcium-channel blocker (CCB). It has been used since 1962 in Europe then in Japan for its antiarrhythmic and coronary vasodilator effects. The CCB have become prominent cardiovascular drugs during the last 15 years. Many experimental and clinical studies have defined their mechanism of action, the effects of new drugs in this ...
P G, Durand, J J, Lehot, P, Foëx
openaire   +3 more sources

Management of lercanidipine overdose with hyperinsulinaemic euglycaemia therapy: case report

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2011
This case report describes the first reported overdose of the dihydropyridine calcium channel blocker (CCB) lercanidipine. A 49 yr old male presented to the Emergency Department 3 hrs after the ingestion of 560 mg of lercanidipine.
Messer Ben, Hafeez Aqib, Hadjipavlou George, Hughes Tom   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Calcium channel blockers‐are they diuretics? [PDF]

British Journal of Clinical Pharmacology, 1985
Seven untreated patients with essential hypertension but without target organ damage were admitted to hospital. Urine was collected the following day from 08.00 to 13.00 h, 13.00 to 18.00 h, and 18.00 to 08.00 h. The protocol was repeated the next day following 30 mg oral nicardipine.
M A, Young, R D, Watson, T J, Stallard, W A, Littler   +3 more
openaire   +2 more sources

SYNTHESIS OF SUBSTITUTED DIHYDROPYRIMIDINES AS HYPOTENSIVE AGENTS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2011
A series of Dihydropyrimidines (DHPMs) with variable substituents at four positions in pyrimidine nucleus (I-IV), were prepared and tested for their calcium channel blocker and hypotensive effect using amlodipine as a reference compound.
Magda Yousri, Adel Youssef, Hoda Hassan, Nawal El-Koussi, Salah Abdel-Aziz   +4 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source