Results 61 to 70 of about 125,774 (261)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Coping with complexity: working beyond the guidelines for patients with multimorbidities [PDF]

, 2015
Primary care physicians believe they are delivering evidence-based care, understanding that adherence to evidence-based clinical guidelines results in tangible benefits in the populations for which they were developed.
Treadwell, Julian
core   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The mechanisms of calcium homeostasis and signalling in the lens [PDF]

, 2008
Excessive Ca2+ can be detrimental to cells and raised levels of Ca2+ in human lenses with cortical cataract have been found to play a major role in the opacification process.
Rhodes, JD, Sanderson, J
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery : the Task Force for Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-cardiac Surgery of the European Society of Cardiology (ESC) and endorsed by the European Society of Anaesthesiology (ESA) [PDF]

, 2009
Non-cardiac surgery; Pre-operative cardiac risk assessment; Pre-operative cardiac testing; Pre-operative coronary artery revascularization; Perioperative cardiac management; Renal disease; Pulmonary disease; Neurological disease; Anaesthesiology; Post ...
Don Poldermans, Jeroen J. Bax, Eric Boersma, Stefan De Hert, Erik Eeckhout, Gerry Fowkes, Bulent Gorenek, Michael G. Hennerici, Bernard Iung, Malte Kelm, Keld Per Kjeldsen, Steen Dalby Kristensen, Jose Lopez-Sendon, Paolo Pelosi, François Philippe, Luc Pierard, Piotr Ponikowski, Jean-Paul Schmid, Olav F.M. Sellevold, Rosa Sicari, Greet Van den Berghe, Frank Vermassen, Sanne E. Hoeks, Ilse Vanhorebeek, Alec Vahanian, Angelo Auricchio, Jeroen J. Bax, Claudio Ceconi, Veronica Dean, Gerasimos Filippatos, Christian Funck-Brentano, Richard Hobbs, Peter Kearney, Theresa McDonagh, Keith McGregor, Bogdan A. Popescu, Zeljko Reiner, Udo Sechtem, Per Anton Sirnes, Michal Tendera, Panos Vardas, Petr Widimsky, Raffaele De Caterina, Stefan Agewall, Nawwar Al Attar, Felicita Andreotti, Stefan D. Anker, Gonzalo Baron-Esquivias, Guy Berkenboom, Laurent Chapoutot, Renata Cifkova, Pompilio Faggiano, Simon Gibbs, Henrik Steen Hansen, Laurence Iserin, Carsten W. Israel, Ran Kornowski, Nekane Murga Eizagaechevarria, Mauro Pepi, Massimo Piepoli, Hans Joachim Priebe, Martin Scherer, Janina Stepinska, David Taggart, Marco Tubaro, Schwartz, Almanaseer, Poldermans, Lee, Boersma, Poldermans, Poldermans, Poldermans, Devereaux, Naughton, Mangano, Ferguson, Carroll, National Center for Health Statistics, Hoeks, Hoeks, Hoeks, Wirthlin, Fleisher, Schouten, Blankensteijn, Holte, Nguyen, Gurusamy, Hlatky, Fletcher, Biccard, Wiklund, Morris, Detsky, Goldman, Maisel, Thygesen, Sabatine, Cannon, Priebe, Tsimikas, Wang, Omland, Bibbins-Domingo, Feringa, Dernellis, Rodseth, Cuthbertson, Cuthbertson, Fox, Jeger, Noordzij, Klocke, Kertai, Etchells, Shaw, Elhendy, Sicari, Das, Nandalur, Rerkpattanapipat, Danias, Hamon, Gerber, Pouleur, Boersma, Reilly, Brunelli, Older, Piepoli, Bassand, Silber, Van de Werf, Cruickshank, Raby, Brady, Juul, Mangano, Yang, Zaugg, Auerbach, McGory, Schouten, Stevens, Bangalore, Devereaux, Wiesbauer, Beattie, Lindenauer, Dunkelgrun, Hoeks, Shammash, Dickstein, Paravastu, van Gestel, Feringa, Boersma, Graham, Rosenson, Hindler, Williams, Durazzo, Schouten, Schouten, Schouten, Coriat, Dodds, Sun, Oosterga, Filion, Wijeysundera, Kertai, Shchukin Iu, Oliver, Wallace, Wijeysundera, Vitez, Macdonald, Shah, Domanski, Lindblad, Robless, Burger, Biondi-Zoccai, Douketis, Vahanian, De Caterina, Pengo, Poldermans, Eagle, Huber, Kaluza, Howard-Alpe, Nuttall, Rabbitts, Douketis, McFalls, Poldermans, Serruys, Kazmers, Hammill, Bhatia, Karagiannis, Feringa, Mancia, Weksler, Iung, Kertai, Vahanian, Habib, Wilson, Forrest, Forrest, Katz, Bertrand, Zipes, Amar, Cox, O'Kelly, Polanczyk, Amar, Atlee, Fuster, Maisel, Balser, Balser, Bayliff, Jakobsen, Mahla, Vardas, Eagle, Gregoratos, Erdman, Potyk, Simon, Shapiro, Madigan, Pinski, Cockcroft, Kertai, Welten, Kheterpal, McCullough, Merten, Maioli, Salem, Murkin, Newman, Selim, Armstrong, Sin, Ramakrishna, Welten, van Gestel, Galiè, Biagini, Leung, Leung, Kaplan, London, Landesberg, Kertai, Landesberg, Martinez, Drew, Landesberg, Fleisher, Mangano, Mangano, London, Eisenberg, Practice guidelines for perioperative transesophageal echocardiography, Polanczyk, Sandham, Feringa, Noordzij, Umpierrez, Vanhorebeek, van den Berghe, Van den Berghe, Gandhi, Ammori, Ellger, Finfer, De Hert, Slogoff, Rodgers, Wu, Bode, Mauermann, Rigg, Birkmeyer, Liu, White, Polomano, Dolin, Jorgensen, Block, Schug   +299 more
core   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Protection Against Cardiac Injury by Small Ca\u3csup\u3e2 +\u3c/sup\u3e-Sensitive K\u3csup\u3e+\u3c/sup\u3e Channels Identified in Guinea Pig Cardiac Inner Mitochondrial Membrane [PDF]

, 2013
We tested if small conductance, Ca2 +‐sensitive K+ channels (SKCa) precondition hearts against ischemia reperfusion (IR) injury by improving mitochondrial (m) bioenergetics, if O2‐derived free radicals are required to initiate protection via SKCa ...
Aldakkak, Mohammed, Camara, Amadou K.S., Cheng, Qunli, Gadicherla, Ashish K., Heisner, James S., Jiang, Ming Tao, Kwok, Wai-Meng, Stowe, David F., Yang, MeiYing, Zhou, Yifan   +9 more
core   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source