Results 91 to 100 of about 153,146 (342)

Do beta-blockers prevent heart disease and strokes in people with high blood pressure? Evidence update - Summary of a Cochrane Review [PDF]

, 2008
In people with high blood pressure, there is no evidence that beta-blockers reduce the number of deaths. Beta-blockers reduce the risk of stroke but are less effective than calcium channel blockers (CCBs) or renin-angiotensin system (RAS ...
Effective Health Care Research Consortium
core  

TRPV4 Contributes to Resting Membrane Potential in Retinal Müller Cells: Implications in Cell Volume Regulation [PDF]

, 2017
Neural activity alters osmotic gradients favoring cell swelling in retinal Müller cells. This swelling is followed by a regulatory volume decrease (RVD), partially mediated by an efflux of KCl and water. The transient receptor potential channel 4 (TRPV4),
Capurro, Claudia Graciela, Di Giusto, Gisela, Fernández, Juan, Ford, Paula, Kalstein, Maia, Netti, Vanina Alejandra, Pizzoni, Alejandro, Rivarola, Valeria   +7 more
core   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]

, 2016
BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus, Maung, Ricky, Medders, Kathryn E, Ojeda-Juárez, Daniel, Sanchez, Ana B, Sánchez-Pavón, Paloma   +5 more
core   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Calcium channel blockers, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors: Effectiveness in combination with diuretics or β-blockers for treating hypertension

Vascular Health and Risk Management, 2007
John D Bisognano1, Trent McLaughlin2, Craig S Roberts3, Simon SK Tang31Internal Medicine Department, Cardiology Division, the University of Rochester Medical Center, Rochester, NY, USA; 2NDC Health, Phoenix, Arizona, USA; 3Pfizer Inc, New York, NY ...
John D Bisognano, Trent McLaughlin, Craig S Roberts, Simon SK Tang   +3 more
doaj  

Calcium Channel Blocker Overdose.

Journal of education & teaching in emergency medicine
Emergency medicine residents and medical students on emergency medicine rotation.Calcium channel blocker (CCB) overdoses can be severe with potentially serious adverse outcomes. CCBs work by blocking the calcium channels on smooth and cardiac muscle tissue. At low dose ranges, dihydropyridine CCBs (such as nifedipine, amlodipine, and nicardipine) block
Andrusaitis, MD, MS, Jessica G., Givertz, MD, Alan   +1 more
openaire   +3 more sources

Health services research in the public healthcare system in Hong Kong: An analysis of over 1 million antihypertensive prescriptions between 2004-2007 as an example of the potential and pitfalls of using routinely collected electronic patient data [PDF]

, 2008
<b>Objectives</b> Increasing use is being made of routinely collected electronic patient data in health services research. The aim of the present study was to evaluate the potential usefulness of a comprehensive database used routinely in the
A McCormack, AL Nightingale, Augustine Lam, AW Hoes, DM Fleming, EE Degli, EPIC, F Trevisani, G Edgren, G Mazzaglia, GC Smith, GL Booth, H Ueshima, Hong Fung, I Nazareth, I Nazareth, InterASIA Collaborative group, J Hollowell, JA Cassell, JB Soriano, JE Hux, JI Williams, Jin-ling Tang, JK Jones, Johnny Y Jiang, JR Hardy, K Tu, KM Madsen, M Ezzati, Martin CS Wong, PM Kearney, R Gupta, R Jones, R Lawrenson, R Lawrenson, RB Singh, RB Singh, RG Gibbs, RJ Cruz-Correia, S Capewell, SS Soedamah-Muthu, Stewart W Mercer, T Karopka, T Walley, TA Burke, TM McKeever, TR Mikuls, TR Mikuls   +47 more
core   +4 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Pills to pearls: Drug-induced gingival overgrowth

Journal of the Practice of Cardiovascular Sciences, 2018
Drug-induced gingival overgrowth is a well-known side effect associated with drugs such as anticonvulsants, calcium-channel blockers, and immunosuppressant. Calcium channel blockers are extensively used in the field of cardiovascular therapeutics.
Varshal J Barot
doaj   +1 more source