Results 91 to 100 of about 98,250 (221)
A quantitative model for presynaptic free calcium dynamics during different stimulation protocols [PDF]
The presynaptic free calcium dynamics of neurons due to various stimulation protocols is investigated in a mathematical model. The model includes calcium influx through voltage-dependent calcium channels, calcium buffering by endogenous and exogenous buffers as well as calcium efflux through ATP-driven plasma membrane calcium pumps and sodium/calcium ...
arxiv
Interaction of verapamil and other calcium channel blockers with alpha 1- and alpha 2-adrenergic receptors. [PDF]
Harvey Motulsky+3 more
openalex +1 more source
Abstract Purpose The dual‐layer multileaf collimator (MLC) in Halcyon adds complexities to the dose calculation process owing to the variability of dosimetric characteristics with leaf motion. Recently, an enhanced leaf model (ELM) was developed to refine the MLC model in the Eclipse treatment planning system. This study investigates the performance of
Ryohei Miyasaka+6 more
wiley +1 more source
Abstract This study evaluates various radiotherapy techniques for treating metastatic brain tumor (BT), focusing on non‐coplanar volumetric modulated arc radiotherapy (NC‐VMAT), coplanar VMAT (C‐VMAT), Helical TomoTherapy (HT), CyberKnife (CK), Gamma Knife (GK), and ZAP‐X.
Toshihiro Suzuki+9 more
wiley +1 more source
Abstract Introduction The use of radioactive materials in the United States has been tightly regulated by the Nuclear Regulatory Commission and other entities for many decades. In 2015, however, the Joint Commission began to require hospital‐based nuclear medicine departments to conduct shielding designs and evaluations for radioactive material areas ...
Michael Oumano+12 more
wiley +1 more source
Lipid-mediated hydrophobic gating in the BK potassium channel [PDF]
The large-conductance, calcium-activated potassium (BK) channel lacks the typical intracellular bundle-crossing gate present in most ion channels of the 6TM family. This observation, initially inferred from Ca$^{2+}$-free-pore accessibility experiments and recently corroborated by a CryoEM structure of the non-conductive state, raises a puzzling ...
arxiv
Interaction of calcium channel blockers with non-neuronal benzodiazepine binding sites. [PDF]
Elinor H. Cantor+3 more
openalex +1 more source
Different insulin-secretory responses to calcium-channel blockers in islets of lean and obese (ob/ob) mice [PDF]
Michael A. Black+3 more
openalex +1 more source
Epitope Mapping of Anti‐Neurofascin 155 Antibody in a Large Cohort of Autoimmune Nodopathy Patients
ABSTRACT Objective Autoimmune nodopathy (AN), a newly recognized disease entity, is an immune‐mediated polyneuropathy involving autoantibodies against cell adhesion molecules located in nodes of Ranvier and paranodal regions, such as neurofascin 186 (NF186) and neurofascin 155 (NF155). The present study aimed to identify the epitopes for autoantibodies
Amina A. Abdelhadi+6 more
wiley +1 more source
Artificial Receptor in Synthetic Cells Performs Transmembrane Activation of Proteolysis
Transmembrane signaling is the hallmark of living cells and is among the highest challenges for the design of synthetic cells. Herein, an artificial receptor based on the chemistry of self‐immolative linkers is used to communicate information across the lipid bilayer, for transmembrane activation of enzymatic activity. Abstract The design of artificial,
Ane Bretschneider Søgaard+7 more
wiley +1 more source