Results 101 to 110 of about 98,250 (221)

Idiopathic Pulmonary Fibrosis Caused by Damaged Mitochondria and Imbalanced Protein Homeostasis in Alveolar Epithelial Type II Cell

Advanced Biology, EarlyView.
By systematizing a large body of evidence and propose a cascade relationship between protein homeostasis, endoplasmic reticulum stress, mitochondrial dysfunction, and pro‐fibrotic factor, providing a theoretical basis for ATII cells dysfunction as a possible pathophysiological initiating event for idiopathic pulmonary fibrosis.
Zhaoxiong Dong, Xiaolong Wang, Peiwen Wang, Mingjian Bai, Tianyu Wang, Yanhui Chu, Yan Qin   +6 more
wiley   +1 more source

The causal relationship between antihypertensive drugs and depression: a Mendelian randomization study of drug targets

Frontiers in Endocrinology
BackgroundDepression ranks as a leading contributor to the global disease burden. The potential causal relationship between the use of antihypertensive medications and depression has garnered significant interest.
Zixian Yang, Jinshuai Li, Peichu Huang, Peichu Huang, Zhichang Li, Jianfeng He, Jianfeng He, Dongchun Cai, Dongchun Cai, Yuzheng Lai, Yuzheng Lai   +10 more
doaj   +1 more source

Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium

Advanced Biology, EarlyView.
The infectious potential of respiratory viruses depends on their ability to navigate through a layer of mucus that serves as a protective barrier in the lung. It is demonstrated that influenza A virus penetration through mucus is significantly limited by the gel's internal microstructure and, to a lesser extent, by adhesive binding to mucin glycans ...
Logan Kaler, Elizabeth M. Engle, Maria Corkran, Ethan Iverson, Allison Boboltz, Maxinne A. Ignacio, Taj Yeruva, Margaret A. Scull, Gregg A. Duncan   +8 more
wiley   +1 more source

Quantitative aspects of L-type calcium currents [PDF]

arXiv, 2011
Calcium currents in neurons and muscle cells have been classified as being one of 5 types of which four, L, N, P/Q and R were said to be high threshold and one, T, was designated low threshold. This review focuses on quantitative aspects of L-type currents.
arxiv  

The calcium channel blocker nitrendipine blocks sodium channels in neonatal rat cardiac myocytes. [PDF]

, 1985
Atsuko Yatani, Arthur Brown
openalex   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

The Evolving Role of Calcium Channel Blockers in Hypertension Management: Pharmacological and Clinical Considerations

Current Issues in Molecular Biology
Worldwide, hypertension is the leading risk factor for cardiovascular disease and death. An estimated 122 million people, per the American Heart Association in 2023, have been diagnosed with this common condition.
Kamryn E. Jones, Shaun L. Hayden, Hannah R. Meyer, Jillian L. Sandoz, William H. Arata, Kylie Dufrene, Corrado Ballaera, Yair Lopez Torres, Patricia Griffin, Adam M. Kaye, Sahar Shekoohi, Alan D. Kaye   +11 more
doaj   +1 more source

Efficacy and mechanism of action of a calcium channel blocker after global cerebral ischemia in rats. [PDF]

, 1988
James C. Grotta, L. Creed Pettigrew, Daniel M. Rosenbaum, Chantelle Reid, Howard M. Rhoades, D. W. McCandless   +5 more
openalex   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

Effects of the Calcium-Channel Blockers Cobalt, Verapamil, and D600 on Leydig Cell Steroidogenesis [PDF]

, 1983
William H. Moger
openalex   +1 more source