FEBS Open Bio, EarlyView.This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili +2 more
wiley +1 more source
Design and synthesis of novel 4-substituted 1,4-dihydropyridine derivatives as hypotensive agents
Journal of Saudi Chemical Society, 2016 Calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. Derivatives of 1,4-dihydropyridines are one of the most potent calcium antagonists.
Prasanna A. Datar, Pratibha B. Auti
doaj +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Fifty‐Four Tablets Too Many: A Case Report of Amlodipine and Losartan Overdose
Clinical Case ReportsOverdoses of widely used cardiovascular drugs calcium channel blockers and angiotensin receptor blockers cause severe hemodynamic instability. Timely management with hyperinsulinemia–euglycemia therapy, vasopressors, and calcium gluconate is critical ...
Nishan Uprety +6 more
doaj +1 more source
The relationship between apamin binding and channel block in KCa2 potassium channels. [PDF]
, 2013 Small conductance calcium-activated potassium channels (KCa2.1,2.2,2.3) are widely distributed throughout the body and are involved in diverse physiological processes including the regulation of neuronal firing and smooth muscle contraction.
Benton, DCH +3 more
core
NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
The Impact of Reference Pricing of Cardiovascular Drugs on Health Care Costs and Health Outcomes: Evidence from British Columbia--Volume II: Technical Report [PDF]
(see SEDAP 70 for abstract)reference pricing,prescription drugs,ACE inhibitors,calcium channel blockers,nitrates,pharmaceutical cost control,seniors,user ...
Adrian R. Levy +4 more
core
Severe hyperkalemia is prevalent and can be detected by quantitative electrocardiographic findings and medication history of calcium channel blocker among the patients with symptomatic or extreme bradycardia [PDF]
, 2013 SB Chon
openalex +1 more source
Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco +18 more
wiley +1 more source
Intravenous Dantrolene Does Not Exhibit Calcium Channel Blocking Effects on the Cardiac Conduction System in Humans [PDF]
, 1991 M. Kentsch +3 more
openalex +1 more source