Results 131 to 140 of about 279,292 (265)

Comparative Effects of Organic and Mineral Calcium Sources on Yield, Nutritional Quality, and Postharvest Storage of Aubergine (<i>Solanum melongena</i> L.). [PDF]

Food Sci Nutr
Stéphanie DMA, Rodrigue BP, Cedric BY, Bertrand KE, Nicolas N.   +4 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

L-Type Voltage-Gated Ca²⁺ Channels Are Targeted by Terpenes from <i>Hyptis crenata</i> Essential Oil in Vascular Electromechanical Coupling. [PDF]

Med Sci (Basel)
Cardeal Dos Santos AN, da Cruz Freire JE, Henrique Félix FS, Araújo MC, Gomes SML, Cabral ALLF, Nascimento AB, Barbosa CC, Vieira Torquato MV, Oliveira LS, Assunção LHB, Brasil SMS, Freitas CB, da Silva JF, Menezes JHA, Pereira-Gonçalves Á, Leal-Cardoso JH, Aquino AJA, Coelho de Sousa AN.   +18 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Enzymatic and Nonenzymatic Antioxidant Systems Affected by the Application of Hydrothermal Treatment and Calcium Chloride in Papaya Fruit. [PDF]

Int J Food Sci
López-Zazueta BA, López-López ME, Gutiérrez-Dorado R, López-Velázquez JG, Díaz-Corona DA, García-Armenta E, Vega-García MO, Ayón-Reyna LE.   +7 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Experimental and computational analysis of SERCA inhibition by naphthoquinone derivatives. [PDF]

Bioorg Med Chem
Cheng S, Kumar S, Sobota S, Drennan A, Johnson N, Maleh S, Almahmodi D, Paula S.   +7 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction. [PDF]

Front Behav Neurosci
Jocsak G, Kiss DS, Alymbaeva D, Diebald A, Zsarnovszky A, Heinzlmann A, Bartha T.   +6 more
europepmc   +1 more source