Results 181 to 190 of about 265,121 (267)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

The efficacy of fluoride varnishes containing different calcium phosphate compounds.

, 2017
Mieczysław Walczak, Anna Turska‐Szybka   +1 more
openalex   +1 more source

Antiviral Activity of a Novel Compound CW-33 against Japanese Encephalitis Virus through Inhibiting Intracellular Calcium Overload [PDF]

, 2016
Su-Hua Huang, Jin‐Cherng Lien, Chao‐Jung Chen, Yu‐Ching Liu, Ching-Ying Wang, Chia-Fong Ping, Yu‐Fong Lin, An‐Cheng Huang, Cheng‐Wen Lin   +8 more
openalex   +1 more source

Quantitative assessment of the usability of electromechanical human-based modelling and simulation to replace Langendorff isolated rabbit heart experiments in the preclinical setting. [PDF]

Front Pharmacol
Holmes M, Martinez-Navarro H, Mohr M, Chambard JM, Ballet V, Vermersch E, Garry A, Schmidt F, Rodriguez B.   +8 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Microcrystalline calcium hydroxyapatite compound in corticosteroid-treated rheumatoid patients: a controlled study. [PDF]

, 1978
K. Haavik Nilsen, M I Jayson, A. St. J. Dixon   +2 more
openalex   +1 more source

Development and evaluation of alginate-based gastroretentive raft-forming systems enabling sustained release of propolis in gastric ulcer treatment. [PDF]

Drug Deliv
Takbirgou H, Salami M, Askari G, Emam-Djomeh Z, Löbenberg R, J Serpe M, Davies NM, Lai WF.   +7 more
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Effect of Mare Nectaris on Feng-flavor Baijiu: an insight into the sensory evaluation and flavor analysis. [PDF]

Front Nutr
Chen Y, Hu J, Zhou F, Meng X, Hu X, Zhang J, Han X.   +6 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source