Elevated glucose changes the expression of ionotropic glutamate receptor subunits and impairs calcium homeostasis in retinal neural cells [PDF]
, 2006 PURPOSE. Altered glutamatergic neurotransmission and calcium homeostasis may contribute to retinal neural cell dysfunction and apoptosis in diabetic retinopathy (DR).
Ambrósio, António F. +5 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Caffeine and Ovariectomy Debilitate Bone Health in Rats on Calcium-deficient Diet [PDF]
Anais da Academia Brasileira de CiênciasThis study investigated the effects of ovariectomy and caffeine intake on bone health in rats on calcium-deficient diet. Forty adults female Wistar rats were divided into 4 groups in a 2x2 factorial design: Ovary (OVX/SHAM) and Caffeine (placebo/caffeine)
FREDERICO S.C. FRANCO +2 more
doaj +1 more source
Indicators of the Element Range of Rat's Blood in Term Artificial Hypobyosis [PDF]
, 2018 The promising method of anesthesia and anesthesia is the state of artificial hypobiosis. Hypercapnia is a prerequisite for creating an artificial carbon dioxide hypobiosis, along with hypoxia and hypothermia.
Kalachnyuk, L. (Lilia) +2 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Effects of Calcium Nutrition on Soybean Growth and Symbiotic Nitrogen Fixation
AgronomyCalcium is essential for legume symbiotic nitrogen fixation, acting as both a nutrient and a signal. Yet, how varying calcium levels—from deficiency to toxicity—affect the soybean ‘root-nodule-stem’ balance has not been fully elucidated.
Sutong Zhao +5 more
doaj +1 more source
EFEKTIFITAS LARUTAN KAPUR [Ca (OH)2] TERHADAP PENURUNAN KADAR PHOSPHAT LIMBAH CAIR PADA UNIT PROSES PENGOLAHAN LIMBAH CAIR(IPLC)RSUP Dr.SOERADJI TIRTO NEGORO KLATEN [PDF]
, 2003 RSUP Dr.Soeradji Tirtonegoro Klaten adalah rumah sakit tipe B pendidikan mempunyai kapasitas tempat tidur 330 buah,dengan rata-rata BOR 68% (mei 2003).adanya dampak negatif yang diakibatkan dari kegiatanya maka RSUP Dr.Soeradji Tirtonegoro Klaten, telah ...
TRIYOKO, SONI
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Annual report 2002 LBI organic fruit growing research [PDF]
, 2002 Overview of projects, project results, funding bodies and partners in 2002 and plans for 2003 Including: SOIL MANAGEMENT * Evaluation of leaf analysis in organic fruit growing as a tool for measuring the uptake of nutrients: Consultants and ...
Bloksma, Joke +2 more
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