Results 181 to 190 of about 1,128,924 (356)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

1,25-Dihydroxyvitamin D₃ injections into rat fetuses : effects on fetal plasma calcium, plasma phosphate and mineral content [PDF]

, 1983
Sylvie Chalon, J.-M. Garel
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Effect of long-term hypokinesia on the electrolytic composition of the blood in patients with osteoarticular tuberculosis [PDF]

Seventy-six patients with osteoarticular tuberculosis were divided into two groups, one of which was required to maintain strict bed rest and the other of which was allowed unrestricted motor activity.
Zakutaeva, V. P.
core   +1 more source

Genotype x environment interaction and its implication in identification of common bean populations with high calcium content

, 2016
Samuel B. Fernandes, Â.F.B. Abreu, Magno Antônio Patto Ramalho   +2 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Calcium content in human saliva

Japanese Journal of Oral Biology, 1975
Michiko TSUDA, Motoharu KAMACHI, Susumu IIZUKA, Kazuko KIRIMURA   +3 more
openaire   +2 more sources

PCC dry; Precipitated Calcium Carbonate (PCC) - dry, uncoated, with a CaCO3 content of 98% or more, a median particle size ranging typically from 1 to 3 µm, ready to be shipped either in bulk or bags. Production at plant.; Production at plant; None (Location: RER)

, 2011
David Pennington, Simone Fazio
openalex   +1 more source

Do low-level laser therapy and platelet-rich plasma affect bone calcium content and mechanical properties at tooth extraction sites? An experimental study in the rat [PDF]

, 2022
Alireza Sharifi, Tahereh Talaei‐Khozani, Nader Tanideh, Hossein Khaje Zadeh, Meysam Haghighat, Sheila Shahsavari-Pour, Saeid Tavanafar   +6 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source