Results 111 to 120 of about 2,715,719 (363)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

COSMOS 2044. Experiment K-7-19. Pineal physiology in microgravity: Relation to rat gonadal function [PDF]

It is now known that the pineal organ can interact with many endocrine and nonendocrine tissues in a regulatory fashion. Given its key role in the regulation of melatonin synthesis, its high concentration, and that its levels may persist longer than the ...
Asadi, H., Holley, D., Krasnov, I., Soliman, M. R. I.   +3 more
core   +1 more source

The Effect of Treatment of Acidosis on Calcium Balance in Patients with Chronic Azotemic Renal Disease [PDF]

, 1967
Small but statistically significant negative calcium balances were found in each of eight studies in seven patients with chronic azotemic renal disease when stable metabolic acidosis was present.
Lemann, Jacob, Jr., Lennon, Edward J., Litzow, John R.   +2 more
core   +3 more sources

Effects of dietary clinoptilolite and calcium levels on the performance and egg quality of commercial layers

Brazilian Journal of Poultry Science, 2013
Among the different feed additives studied in poultry production, clinoptilolite, an aluminosilicate capable of adsorbing harmful substances and of improving live performance and egg and meat quality, was evaluated. The objective of the present study was
DA Berto, EA Garcia, K Pelícia, F Vercese, A de B Molino, AF da Silveira, JA Vieira Filho, ESF Murakami   +7 more
doaj   +1 more source

Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death.

Circulation Research, 2020
Adult cardiomyocytes are postmitotic cells that undergo very limited cell division. Thus, cardiomyocyte death as occurs during myocardial infarction has very detrimental consequences for the heart.
Tyler M. Bauer, E. Murphy
semanticscholar   +1 more source

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source

An investigation into the effects of Omega-3 fatty acids on bone resorption in the female ovariectomised rat : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Nutritional Science at Massey University [PDF]

, 2004
Estrogen deficiency results in disruption of the normal bone remodeling cyclc leading to a loss of bone mineral and, in many cases, the development of osteoporosis.
Poulsen, Raewyn Carol
core  

Effect of vitamin D supplementation on blood pressure:a systematic review and meta-analysis incorporating individual patient data [PDF]

, 2015
D-PRESSURE Collaboration: et al.[Importance]: Low levels of vitamin D are associated with elevated blood pressure (BP) and future cardiovascular events.
Alvarez, Jessica, Beveridge, Louise A., Boxer, Rebecca, Dalbeni, Andrea, Gepner, Adam D., Isbel, Nicole M., Jorde, Rolf, Khan, Faisel, Larsen, Thomas, Macdonald, Helen M., Nagpal, Jitender, Petchey, William G., Scragg, Robert, Stricker, Hans, Stroebel, Franziska, Struthers, Allan D., Tangpricha, Vin, Toxqui, Laura, Vaquero, M. Pilar, Wamberg, Louise, Witham, Miles D., Zittermann, Armin   +21 more
core   +3 more sources

Characterization of the norepinephrine-activation of adenylate cyclase suggests a role in memory affirmation pathways. Overexposure to epinephrine inactivates adenylate-cyclase,a causal pathway for stress-pathologies [PDF]

BioSystems 100 (2010) p. 87-93, 2010
Incubation with noradrenaline (norepinephrine) of isolated membranes of rat's brain corpus striatum and cortex, showed that ionic-magnesium (Mg2+) is required for the neurotransmitter activatory response of Adenylate Cyclase [ATP pyrophosphate-lyase (cyclizing), (EC 4.6.1.1)], AC.An Mg2+-dependent response to the activatory effects of adrenaline, and ...
arxiv