Results 131 to 140 of about 2,715,719 (363)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Strontium metabolism in the rebuilding of skeletal tissue [PDF]

The relationship between calcium and strontium in bone metabolism is described. Whole body comparisons in the form of balance studies, plasma kinetics, and biochemical bone differences are briefly reviewed. The value of strontium as a qualitative calcium

core   +1 more source

The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion. [PDF]

, 2012
Mitochondria mediate dual metabolic and Ca(2+) shuttling activities. While the former is required for Ca(2+) signalling linked to insulin secretion, the role of the latter in β cell function has not been well understood, primarily because the molecular ...
Fishman, Daniel, Hershfinkel, Michal, Khananshvili, Daniel, Lewis, Eli C, Nita, Iulia I, Ozeri, Eyal, Rutter, Guy A, Sekler, Israel, Sensi, Stefano L   +8 more
core   +2 more sources

Dynamics of intracellular Ca$^{2+}$ oscillations in the presence of multisite Ca$^{2+}$-binding proteins [PDF]

, 2009
We study the dynamics of intracellular calcium oscillations in the presence of proteins that bind calcium on multiple sites and that are generally believed to act as passive calcium buffers in cells. We find that multisite calcium-binding proteins set a sharp threshold for calcium oscillations. Even with high concentrations of calcium-binding proteins,
arxiv   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Long-term trends of changes in pine and oak foliar nitrogen metabolism in response to chronic nitrogen amendments at Harvard Forest, MA [PDF]

, 2015
We evaluated the long-term (1995–2008) trends in foliar and sapwood metabolism, soil solution chemistry and tree mortality rates in response to chronic nitrogen (N) additions to pine and hardwood stands at the Harvard Forest Long Term Ecological Research
Long, Stephanie, McDowell, William H., Minocha, Rakesh, Minocha, Subhash C., Turlapati, Swathi A.   +4 more
core   +2 more sources

Calcium metabolism in health and disease.

American Society of Nephrology. Clinical Journal, 2010
This brief review focuses on calcium balance and homeostasis and their relationship to dietary calcium intake and calcium supplementation in healthy subjects and patients with chronic kidney disease and mineral bone disorders (CKD-MBD).
M. Peacock
semanticscholar   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Effect of carbohydrate feeding on the bone metabolic response to running [PDF]

, 2015
Bone resorption is increased after running, with no change in bone formation. Feeding during exercise might attenuate this increase, preventing associated problems for bone. This study investigated the immediate and short-term bone metabolic responses
Craig Sale, Ian Varley, Jonathan C. Y. Tang, Julie P. Greeves, Peake JM, Ruth M. James, Thomas W. Jones, William D. Fraser, Zweig MH   +8 more
core   +1 more source

Gene Mapping and Gene-Set Analysis for Milk Fever Incidence in Holstein Dairy Cattle

Frontiers in Genetics, 2018
Milk fever is an important metabolic disorder that affects dairy cows around parturition. It is associated with a breakdown in the mechanisms of calcium homeostasis, resulting in very low blood calcium levels (hypocalcemia).
Hendyel A. Pacheco, Hendyel A. Pacheco, Simone da Silva, Simone da Silva, Anil Sigdel, Chun Kuen Mak, Klibs N. Galvão, Rodrigo A. Texeira, Laila T. Dias, Francisco Peñagaricano, Francisco Peñagaricano   +10 more
doaj   +1 more source