Results 141 to 150 of about 2,493,792 (352)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Role of calcium metabolism in ADHD: The relationship between parathyroid hormone and ADHD symptom severity. [PDF]

open access: yesIndian J Psychiatry, 2022
Altun Varmiş D   +7 more
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction

open access: green, 2007
Laura Ahtiainen   +8 more
openalex   +2 more sources

Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism

open access: gold, 2022
Brittany Stork   +15 more
openalex   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

open access: yesFEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani   +7 more
wiley   +1 more source

The Neurospora crassa PCL-1 cyclin is a PHO85-1 (PGOV) kinase partner that directs the complex to glycogen metabolism and is involved in calcium metabolism regulation. [PDF]

open access: yesFront Microbiol, 2022
Campanella JEM   +8 more
europepmc   +1 more source

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