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Calcium-channel blockers in the treatment of migraine

The American Journal of Cardiology, 1985
According to classic theory, a migraine attack is initiated by cerebrovascular spasm followed by extracranial vasodilatation. Results of recent studies support this theory and suggest that cerebral blood flow during the initial phase of migraine symptoms is, in fact, decreased and this decrease probably leads to ischemia and hypoxia.
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Calcium antagonists in the treatment of arterial hypertension

American Heart Journal, 1993
Calcium antagonists are widely used antihypertensive agents whose hemodynamic effects consist of a reduction in blood pressure and peripheral vascular resistance that is associated, in case of short-term administration, with a reflex increase in heart rate and cardiac output.
G, Parati, G, Mancia
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Calcium Carbimide in the Treatment of Primary Hyperoxaluria

New England Journal of Medicine, 1967
A DEFECT in the transamination of glyoxalate has been suggested as the metabolic abnormality responsible for the increased rate of oxalate synthesis in patients with primary hyperoxaluria (Fig. 1).1 Some of this excess oxalate combines with calcium to form insoluble deposits in a variety of tissues, resulting, in the kidney, in extensive scarring and ...
C C, Solomons, S I, Goodman, C M, Riley
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CALCIUM TREATMENT FOR EDEMA

Archives of Internal Medicine, 1924
Meyer and Cohn,1in 1911, studied the effect of various salts on the weight and mineral balance in normal infants. They found that by giving calcium salts they could cause a decrease in weight due to water loss. In the case of calcium chlorid, they found that the calcium ion seemed to be largely excreted in the stool, while the chlorin ion was excreted ...
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Calcium Antagonists in the Treatment of Hypertension

Journal of Cardiovascular Pharmacology, 1990
Treatment of hypertension constitutes an important part of all medical care provided in industrialized countries today. During the last three to four decades, several groups of effective and well-tolerated antihypertensive compounds have become clinically available, e.g., the thiazide diuretics, the centrally acting sympatholytic drugs, the ...
L, Hansson, B, Dahlöf
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Treatment of Primary Hyperoxaluria with Calcium Carbimide

New England Journal of Medicine, 1967
VARIOUS measures have been proposed to reduce the endogenous production of oxalic acid in patients with primary hyperoxaluria; these include the oral administration of sodium benzoate,1 pyridoxine,2 hydroxymethane sulfonic acid3 and allopurinol.4 Recently, Solomons and his colleagues5 have proposed the use of calcium carbimide on the grounds that this ...
P M, Zarembski   +2 more
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Calcium Dobesilate in the Treatment of Diabetic Retinopathy

Treatments in Endocrinology, 2005
The incidence of diabetic retinopathy is still increasing in developed countries. Tight glycemic control and laser therapy reduce vision loss and blindness, but do not reverse existing ocular damage and only slow the progression of the disease. New pharmacologic agents that are currently under development and are specifically directed against clearly ...
Ricardo P, Garay   +2 more
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Calcium antagonists in the treatment of Tourette's disorder

American Journal of Psychiatry, 1986
Two patients with Tourette's disorder were treated with calcium antagonists. Verapamil and nifedipine produced positive responses, and diltiazem produced no response. Given the negative side effects of the current drugs for this disorder, the authors suggest further study of calcium antagonists.
T L, Walsh   +4 more
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Calcium antagonists for the treatment of systemic hypertension

The American Journal of Cardiology, 1992
As shown by large-scale clinical trials, the antihypertensive effectiveness of diuretics has been associated with a dramatic decrease in the incidence of stroke. This decrease, however, has not been accompanied by a similar reduction in atherosclerotic complications of hypertension, perhaps because other risk factors are important contributors to ...
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Migraine Treatment with Calcium Channel Blockers

Acta Pharmacologica et Toxicologica, 1986
Abstract: Irrespective of their mechanism of action, which so far has not been clarified, calcium channel blockers (CCBs) have a documented prophylactic effect on classical and common migraine, as well as on cluster headache. The drugs may reduce migraine prodromes, the frequency of migraine attacks, and also decrease the severity and possibly the ...
K E, Andersson   +3 more
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