Results 31 to 40 of about 5,292 (217)
LIPIcs, Volume 72, CALCO'17, Complete Volume
, 2017 LIPIcs, Volume 72, CALCO'17, Complete ...
König, Barbara, Bonchi, Filippo
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British Journal of Pharmacology, Volume 183, Issue 13, Page 3866-3884, July 2026.Abstract Background and Purpose The absence of the protein dystrophin in Duchenne muscular dystrophy (DMD) leads to progressive muscle weakness, failing regeneration and deregulation of nitric oxide (NO) signalling. We focused on L‐citrulline, a precursor of L‐arginine, required for NO production in muscle, which is reduced in dystrophic mdx muscle ...
Lisamaura Tulimiero +14 more
wiley +1 more source
Journal of Neurochemistry, Volume 170, Issue 7, July 2026.In this study, human astrocytes were obtained from induced pluripotent stem cells (iPSCs) of Parkinson's disease (PD) patients carrying the G2019S LRRK2 mutation, the most common genetic cause of PD. These astrocytes display a reactive and inflammatory profile, with increased GFAP levels, elevated cytokine release, and reduced support for dopaminergic ...
Veronica Mutti +13 more
wiley +1 more source
The endogenous cannabinoid system gates plasticity of tonic GABA inhibition
The Journal of Physiology, Volume 604, Issue 12, Page 4984-5010, 15 June 2026.Abstract figure legend Postsynaptic depolarisation and increases in intracellular Ca2+ ([Ca2+]i) trigger the synthesis of endocannabinoids (eCBs), which are hypothesised to enhance tonic GABAergic inhibition via two primary pathways. In the proposed autocrine mechanism, eCBs activate postsynaptic somatodendritic or mitochondrial CB1 receptors ...
Roberto Colangeli, Fiorenzo Conti
wiley +1 more source
Advanced Science, Volume 13, Issue 30, 28 May 2026.A biodegradable molecularly imprinted polymer porous silica sensor enables dual optical readout of doxorubicin via fluorescence and effective optical thickness shifts. The combined transduction mechanisms provide enhanced reliability and quantitative accuracy over clinically relevant concentrations, representing a step toward transient implantable ...
Martina Corsi +11 more
wiley +1 more source
Regulation of the Enzymes of the Hydroaromatic Pathway in Acinetobacter calco-aceticus [PDF]
Journal of General Microbiology, 1971 Summary: The synthesis of dehydroquinase, dehydroshikimate dehydrase and the other enzyme of the hydroaromatic pathway, the hydroaromatic dehydrogenase, was product-induced by protocatechuate in Acinetobacter calco-aceticus. The enzymes of the hydroaromatic pathway and those which subsequently break down protocatechuate are subject to a high degree of ...
W. M. INGLEDEW +2 more
openaire +1 more source
Deep learning‐enhanced 3D imaging unveils semaglutide impact on cardiac fibrosis
British Journal of Pharmacology, Volume 183, Issue 5, Page 1030-1047, March 2026.Background and Purpose Myocardial fibrosis (MF), a hallmark of structural cardiac remodelling, drives disease progression across most forms of heart failure and plays a central role in heart failure with preserved ejection fraction (HFpEF). Despite its clinical relevance, effective treatments remain scarce.
Sheyla Barrado‐Ballestero +11 more
wiley +1 more source
Journal of Cellular Physiology, Volume 241, Issue 2, February 2026.Schematic diagram showing dose‐dependent effects of PA in oligodendrocyte precursor MO3.13 cells and rodent organotypic hippocampal and cerebellar slice cultures. High doses lead to cell death accompanied by mitochondrial impairment, whereas low doses activate the Nrf2 antioxidant response and exert neuroprotective effect while balancing mitochondrial ...
Anna Palmiero +12 more
wiley +1 more source
Configuración urbana de Turín en La bella estate
Cuadernos de Filología Italiana, 2012 Desarrollada en una ciudad calco de Turín pero nunca identificada realmente con ella, el espacio urbano se concibe como una ciudad imaginada en torno a la protagonista del relato, Ginia.
Edmundo Garrido Alarcón
doaj +1 more source
The HIF‐1α Pathway Regulates Satellite Cell Fate During Aging Through Histone Lactylation
Aging Cell, Volume 25, Issue 2, February 2026.FG‐4592–induced activation of HIF‐1α enhances anaerobic glycolysis and promotes lactate‐driven PAX7 lactylation, thereby boosting satellite cell activity and counteracting age‐related muscle decline. ABSTRACT Aging‐associated sarcopenia is driven in part by the progressive loss of type II glycolytic fibers and the functional decline of their resident ...
Marco Piccoli +15 more
wiley +1 more source