Results 51 to 60 of about 5,292 (217)

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

British Journal of Pharmacology, Volume 182, Issue 22, Page 5574-5595, November 2025.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela   +16 more
wiley   +1 more source

Novel 4,5‐Dihydrothiazole‐Phenylpiperazine Derivatives: Synthesis, Docking Studies and Pharmacological Evaluation as Serotonergic Agents

ChemMedChem, Volume 20, Issue 15, August 2, 2025.
The synthesis of a new series of 4,5‐dihydrothiazol‐2‐ylphenylpiperazine derivatives as serotoninergic ligands is described and tested for their affinity toward 5‐HT1A, 5‐HT2A,and 5‐HT2C and selected for further in vivo assays to determine their functional activity. The pharmacological studies highlight that among the developed derivatives, FG‐7 and FG‐
Giorgia Andreozzi, Natalia Karkoszka, Rosa Sparaco, Angela Corvino, Beatrice Severino, Vincenzo Santagada, Elisa Magli, Ewa Gibuła‐Tarłowska, Jolanta H. Kotlińska, Kinga Gawel, Raffaele Capasso, Anna Lesniak, Nataliia Semenko, Agnieszka A. Kaczor, Anna Bielenica, Grażyna Biała, Giuseppe Caliendo, Ewa Kędzierska, Ferdinando Fiorino   +18 more
wiley   +1 more source

A Novel Cognitive Frailty Index for Geriatric Mice

Aging Cell, Volume 24, Issue 7, July 2025.
Our study presents a groundbreaking longitudinal assessment of age‐related cognitive decline in a large cohort of aged mice. Through the development of the Cognitive Frailty Index (CoFI), we introduce a robust metric that correlates strongly with advancing age and mortality.
Serena Marcozzi, Giorgia Bigossi, Maria Elisa Giuliani, Giovanni Lai, Beatrice Bartozzi, Marta Balietti, Tiziana Casoli, Fiorenza Orlando, Andrea Amoroso, Robertina Giacconi, Maurizio Cardelli, Francesco Piacenza, Fabrizia Lattanzio, Fabiola Olivieri, Peter L. J. de Keizer, Fabrizio d’Adda di Fagagna, Marco Malavolta   +16 more
wiley   +1 more source

Geochemical constraints on the origin of calcalkaline and alkaline magmas of the eastern Trans-Mexican Volcanic Belt

Geofísica Internacional, 1988
Se presentan datos de elementos mayores, elementos trazas y tierras raras de rocas calco-alcalinas y alcalinas de la parte este del Cinturón Volcánico Transmexicano (TMVB), así como conclusiones acerca de su origen y de su significado tectónico.
Th. Besch, J. F. W. Negendank, R. Emmermann, H. J. Tobschall   +3 more
doaj   +1 more source

Bioresorbable and Wireless Rechargeable Implanted Na‐ion Battery for Temporary Medical Devices

Advanced Functional Materials, Volume 35, Issue 23, June 5, 2025.
An all‐solid‐state bioresorbable Na‐ion battery is developed, composed entirely of bio‐eliminable materials. In vivo and ex vivo tests confirmed harmless disintegration of this implanted battery. Lifetime of the implanted battery can be precisely controlled by adjusting the dissolvable encapsulation layer's thickness.
Vedi Kuyil Azhagan Muniraj, Bincy Lathakumary Vijayan, Hussien Hammoud, Roger Delattre, Marc Ramuz, Eve Djenizian, Eleonora Vandini, Daniela Giuliani, Thierry Djenizian   +8 more
wiley   +1 more source

Appropriazione di un deposito per affrancamento (παρακαταθήκη εἰς ἐλευθερίαν) da Delo: una rilettura di I.Délos 2531

Historika : Studi di Storia Greca e Romana
Il presente saggio, che nasce all’interno di un’indagine da me condotta sulle cd. prayers for justice nel mondo greco, è dedicato all’iscrizione I.Délos 2531.
Elisa Daga
doaj   +1 more source

« With what face can you look up, thou shame of heaven and man?». The monologue to one’s penis from the Satyricon to Fellini Satyricon

Between, 2016
Questo lavoro muove dal puntuale riferimento al frammento 132, 8-16 del Satyricon antico, porzione di testo che mette in scena un disinvolto e superbo monologo al proprio membro, presa in giro di ogni impasse sessuale, calco parodico dell’Odissea.
Emanuele Canzaniello
doaj   +1 more source

Fructose‐Induced Impairment of Liver and Skeletal Muscle Metabolism Is Prevented by Administration of Shouchella clausii Spores by Preserving Mitochondrial Function and Insulin Sensitivity

Molecular Nutrition &Food Research, Volume 69, Issue 11, June 2025.
S. clausii SF174 spores were effective in preventing the onset of low‐grade inflammation and insulin resistance induced by fructose‐rich diet in young rats, preserving the mitochondria from changes in the respiratory capacity in both liver and skeletal muscle, maintaining unaltered the oxidative balance, thus counteracting the deleterious effects of ...
Angela Di Porzio, Valentina Barrella, Anella Saggese, Loredana Baccigalupi, Luisa Cigliano, Ezio Ricca, Susanna Iossa, Arianna Mazzoli   +7 more
wiley   +1 more source

Sr-Nd-Pb isotope and trace element geochemistry of calc-alkaline andesites from Volcán Colima, Mexico

Geofísica Internacional, 1993
Se reportan los datos de elementos traza y las composiciones isotópicas de Sr, Nd y Pb en andesitas calco-alcalinas del Volcán Colima y se comparará con otros centros volcánicos del Cinturón Volcánico Mexicano.
Surendra P. Verma, James F. Luhr
doaj   +1 more source

Temperantia y continentia en el pensamiento aristotélico de Alfonso de Cartagena (con un breve excurso acerca de la 'mantenençia' ruiziana)

Revista de Poética Medieval, 2018
La exposición acerca de la temperantia y la continentia recogida en el Memoriale virtutum de Alfonso de Cartagena (1422) es calco en gran medida de la reflexión tomista al respecto, pero también se modula según algunas de las convicciones teóricas más ...
Ángel Escobar
doaj   +1 more source