Results 41 to 50 of about 165,154 (301)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

On the Hybrid Fourth Power Mean Involving Legendre’s Symbol and One Kind Two-Term Exponential Sums

Journal of Mathematics, 2021
The main purpose of this article is using the elementary methods and the properties of the quadratic residue modulo an odd prime p to study the calculating problem of the fourth power mean of one kind two-term exponential sums and give an interesting ...
Jingzhe Wang
doaj   +1 more source

A Multivariate Lagrange Inversion Formula for Asymptotic Calculations [PDF]

The Electronic Journal of Combinatorics, 1998
The determinant that is present in traditional formulations of multivariate Lagrange inversion causes difficulties when one attempts to obtain asymptotic information. We obtain an alternate formulation as a sum of terms, thereby avoiding this difficulty.
Edward A. Bender, L. Bruce Richmond
openaire   +2 more sources

A gradient formula for linear chance constraints under Gaussian distribution [PDF]

, 2011
We provide an explicit gradient formula for linear chance constraints under a (possibly singular) multivariate Gaussian distribution. This formula allows one to reduce the calculus of gradients to the calculus of values of the same type of chance ...
Henrion, René, Henrion, René, Möller, Andris, Möller, Andris   +3 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

On the generalized exponential sums and their fourth power mean

Open Mathematics
The main purpose of this article is to study the calculating problem of the fourth power mean of the two-term exponential sums and provide an accurate calculating formula for utilizing analytical methods and character sums’ properties. In the meantime, a
Liu Wencong, Ning Shushu
doaj   +1 more source

Methods of Calculating Moisture Discharge Characteristics of Insulators [PDF]

Problems of the Regional Energetics
The article discusses methods for calculating the moisture discharge voltage of insulators under various operating conditions (pollution, humidity, etc.) to identify patterns of environmental influence on operational characteristics, as well as to ...
Shevchenko S., Danylchenko D., Hanus R., Radohuz S., Tomashevskiy R., Makhonin M., Potryvai A.   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A closed-form formula for calculating the Fourier transform of time-limited signals [PDF]

, 2014
A new method for calculating the Fourier transform of a function is developed. This method is based on the generalization of the jump formula which is used in calculating the Fourier series of periodic functions.
Moradi, Gholamreza
core