Results 61 to 70 of about 214,662 (263)

Exploration and Practice of a New Formula for Calculating the Degree of Freedom

MATEC Web of Conferences, 2018
The current “structural mechanics” in the textbook, the more sub items in the formula of calculating degrees of freedom, is not conducive for the students to master the understanding and calculation of degree of freedom concept.
Yangxiaochi
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Calculation algorithm of additional stresses in irregularly shaped foundation soils under non-uniform loading

Scientific Reports
The classical calculation method of additional stresses in foundation soils was established based on the Flamant and Boussinesq solutions in elasticity theory.
Shuai Wang, Zechu Zhang, Xiangdong Zhang
doaj   +1 more source

The bridge between design and analysis

Perspectives on Medical Education, 2017
The overall purpose of the ‘Statistical Points and Pitfalls’ series is to help readers and researchers alike increase awareness of how to use statistics and why/how we fall into inappropriate choices or interpretations. We hope to help readers understand
Jimmie Leppink, Patricia O’Sullivan, Kal Winston   +2 more
doaj   +1 more source

TABLES FOR CHEMICAL CALCULATIONS, WITH EXPLANATIONS AND ILLUSTRATIVE EXAMPLES. [PDF]

Journal of the American Chemical Society, 1905
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openaire   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Theoretical basics of applying the one dimensional problem of soils compression seal theory to large foundation plates calculation

MATEC Web of Conferences, 2016
Calculation of compressed footings settlement is one of the most vital tasks of soil mechanics. The calculation method of layer-by-layer addition, which recommended by current regulations and used in structural engineering practice, is most suitable for ...
Isaev Veniamin, Maltsev Andrei, Karpov Andrei   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source