KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Calculation Method for Hydrogen Evolution and Adsorption on Ir, Pt, and Ir-Pt Nanocatalysts Supported on Porous Carbon Electrodes in Water Electrolysis. [PDF]
ACS OmegaTaherkhani F, Mauss F.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Calculation method and predictive analysis of flexural capacity of reinforced concrete beams strengthened with carbon fiber-reinforced polymer sheets applied to the side surfaces. [PDF]
PLoS OneLiu X.
europepmc +1 more source
Calculation method of image morphing and its applications
, 2011 To transform one image into another fluidly by geometric deformation and color blending, the paper proposes a calculation method of image morphing based on a self-defined coordinate system called triangle coordinate system.
Wang, Shoujue +2 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Free Energy Calculation Method Based on Enhanced Sampling of Diverse Protein Conformations Predicted by Artificial Intelligence. [PDF]
J Phys Chem LettAoki T, Harada R.
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Bearing characteristics and settlement calculation method of pile groups in beaded karst areas. [PDF]
PLoS OneLi J +6 more
europepmc +1 more source
Fast Hologram Calculation Method Based on Wavefront Precise Diffraction. [PDF]
Micromachines (Basel), 2023 Wang Z, Li Y, Tang Z, Li Z, Wang D.
europepmc +1 more source