Results 151 to 160 of about 12,609,494 (300)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Quantifying sorptivity using the contact sponge method: an improved calculation method validated by classical capillary rise experiments and neutron radiography. [PDF]

Mater Struct
Derluyn H, Desarnaud J, Vandevoorde D, Dewanckele J, Boone MN, Peetermans S, Lehmann E, Viles H, Cnudde V.   +8 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Discussion and calculation of circumferential stress of buried pipeline under traffic load

管道保护
In order to study the distribution law and calculation method of circumferential stress of buried pipeline under traffic load, by comparing the measured results of field test with the existing theoretical calculation results, it was found that due to the
He Bai, Pengfei Wang
doaj  

Two-Dimensional Image Lempel-Ziv Complexity Calculation Method and Its Application in Defect Detection. [PDF]

Entropy (Basel)
Yin J, Sui W, Zhuang X, Sheng Y, Li Y.
europepmc   +1 more source

Vibration of railway bridges in the audible frequency range

, 2009
The noise level associated with a train travelling on a bridge is normally greater than that for a train travelling on plain track. It is sometimes the bridge noise that causes the highest levels of disturbance to people in the vicinity or triggers ...
Herron, David
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

适用于系留气球载物运输的多索控制及计算方法

工程科学与技术
Objective At present, transmission lines are often located in high mountains and steep ridges, and material transportation is an urgent problem to be solved.
秦剑, 何荣浩, 刘晨, 周亚傲, 王飞   +4 more
doaj  

Calculation method of canopy effective volume for fruit tree based on LiDAR point cloud data. [PDF]

Front Plant Sci
Ma H, Wang K, Ma J, Jiang S, Liu P, Yang C, Wang D, Cui H, Chang H.   +8 more
europepmc   +1 more source

Novel Calculation Method for the Shear Capacity of a UHPC Beam with and without Web Reinforcement. [PDF]

Materials (Basel), 2023
Gao C, Jiang H, Zhang G, Chen L, Hu Y.
europepmc   +1 more source