Results 91 to 100 of about 146,242 (384)
Advanced ScienceThe mTOR inhibitor everolimus has been approved as a sequential or second‐line therapy for renal cell carcinoma (RCC). However, the development of drug resistance limits its clinical applications.
Yu Luo +14 more
doaj +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
Gallstone ileus with a biliodigestive fistula
Journal of the Belgian Society of Radiology, 2013 Background: A 34-year-old woman with breast cancer, metastasized to bone and brain, was admitted to our hospital with abdominal discomfort, nausea and constipation. Physical examination revealed a diffuse tender abdomen without bowel sounds.
LJ Schijf +3 more
doaj +1 more source
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
Distilling Abstract Machines (Long Version) [PDF]
, 2014 It is well-known that many environment-based abstract machines can be seen as strategies in lambda calculi with explicit substitutions (ES). Recently, graphical syntaxes and linear logic led to the linear substitution calculus (LSC), a new approach to ES
Accattoli, Beniamino +2 more
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Fibrations and Calculi of Fractions
BRICS Report Series, 1994 Given a fibration E -> B and a class Sigma of arrows of B, one can construct the free fibration (on E over B such that all reindexing functors over elements of Sigma are equivalences.<br /> <br />In this work I give an explicit construction of this, and study its properties.
openaire +6 more sources
Urinary Calculi and Risk of Cancer
Medicine, 2014 Previous studies have shown that urinary calculi are associated with increased risks of urinary tract cancers. However, the association between urinary calculi and overall cancers is a largely undefined body of knowledge.We conducted a nationwide ...
Chia‐Jen Shih +5 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Outcomes of flexible ureteroscopic lithotripsy with holmium laser for upper urinary tract calculi
International Brazilian Journal of Urology, 2008 OBJECTIVE: To assess the perioperative and financial outcomes of flexible ureteroscopic lithotripsy with holmium laser for upper tract calculi in 44 patients.
Marcello Cocuzza +6 more
doaj +1 more source
A Histomorphological Pattern of Gallbladder Lesions in a Tertiary Hospital in Southwestern Nigeria: A Retrospective Descriptive Study [PDF]
Rwanda Medical Journal, 2021 BACKGROUND: The gallbladder is one of the most common specimens encountered in the surgical pathology laboratory, and gallstone related diseases are among the most common medical problems requiring surgical intervention.
M. A. Ajani et al.
doaj