Results 91 to 100 of about 147,549 (388)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A vesicocutaneous fistula secondary to bladder calculi in a patient with spina bifida

Journal of Surgical Case Reports, 2010
We present a rare case of a vesicocutaneous fistula secondary to two large bladder calculi in a patient with spina bifida. A 62 year old lady presented with swelling of her right thigh and a calcified mass protruding through the subcutaneous tissues of ...
Jonathan D Horsnell, Richard B Kinder
doaj  

Distilling Abstract Machines (Long Version) [PDF]

, 2014
It is well-known that many environment-based abstract machines can be seen as strategies in lambda calculi with explicit substitutions (ES). Recently, graphical syntaxes and linear logic led to the linear substitution calculus (LSC), a new approach to ES
Accattoli, Beniamino, Barenbaum, Pablo, Mazza, Damiano   +2 more
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Gallstone ileus with a biliodigestive fistula

Journal of the Belgian Society of Radiology, 2013
Background: A 34-year-old woman with breast cancer, metastasized to bone and brain, was admitted to our hospital with abdominal discomfort, nausea and constipation. Physical examination revealed a diffuse tender abdomen without bowel sounds.
LJ Schijf, D Van der Vlies, AG Aalbers, A Bruining   +3 more
doaj   +1 more source

Sequent and Hypersequent Calculi for Abelian and Lukasiewicz Logics [PDF]

, 2002
We present two embeddings of infinite-valued Lukasiewicz logic L into Meyer and Slaney's abelian logic A, the logic of lattice-ordered abelian groups. We give new analytic proof systems for A and use the embeddings to derive corresponding systems for L ...
Gabbay, D., Metcalfe, G., Olivetti, N.
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

A Framework for Program Development Based on Schematic Proof [PDF]

, 1993
Often, calculi for manipulating and reasoning about programs can be recast as calculi for synthesizing programs. The difference involves often only a slight shift of perspective: admitting metavariables into proofs. We propose that such calculi should be
Basin, David, Bundy, Alan, Kraan, Ina, Matthews, Sean   +3 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Outcomes of flexible ureteroscopic lithotripsy with holmium laser for upper urinary tract calculi

International Brazilian Journal of Urology, 2008
OBJECTIVE: To assess the perioperative and financial outcomes of flexible ureteroscopic lithotripsy with holmium laser for upper tract calculi in 44 patients.
Marcello Cocuzza, Jose R. Colombo Jr, Antonio L. Cocuzza, Frederico Mascarenhas, Fabio Vicentini, Eduardo Mazzucchi, Miguel Srougi   +6 more
doaj   +1 more source