Results 51 to 60 of about 147,549 (388)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Ureteroscopic treatment of larger renal calculi (\u3e2 cm). [PDF]

, 2012
OBJECTIVES: To evaluate the current status of ureteroscopic lithotripsy (UL) for treating renal calculi of \u3e2 cm, as advances in flexible ureteroscope design, accessory instrumentation and lithotrites have revolutionised the treatment of urinary ...
Bagley, Demetrius H., Healy, Kelly A., Kleinmann, Nir   +2 more
core   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Efficacy Evaluation of the Phytotherapeutic Drug Canephron N in the Complex Treatment of Patients with Urolithiasis Using Extracorporeal Shock Wave Lithotripsy [PDF]

, 2018
The study objective was to analyse the effect of the herbal drug Canephron N, namely, its ability to potentiate the efficacy of extracorporeal shock wave lithotripsy (ESWL) in the treatment of patients with urolithiasis (UL) and prevent recurrence of ...
Vitkovskyy, V. (Volodymir)
core   +2 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

A machine learning framework for accurately recognizing circular RNAs for clinical decision-supporting

BMC Medical Informatics and Decision Making, 2020
Background Circular RNAs (circRNAs) are those RNA molecules that lack the poly (A) tails, which present the closed-loop structure. Recent studies emphasized that some circRNAs imply different functions from canonical transcripts, and further associated ...
Yidan Wang, Xuanping Zhang, Tao Wang, Jinchun Xing, Zhun Wu, Wei Li, Jiayin Wang   +6 more
doaj   +1 more source

Are Newer Extracorporeal Shock Wave Lithotripsy Models Truly Improving Pancreatolithiasis Lithotripsy Performance? A Japanese Single-Center Study Using Endoscopic Adjunctive Treatment

Gut and Liver, 2023
Background/Aims: Many Japanese institutions use electromagnetic extracorporeal shock wave lithotripsy (ESWL) systems for treating pancreatic duct stones.
Ken Ito, Naoki Okano, Kensuke Takuma, Susumu Iwasaki, Koji Watanabe, Yusuke Kimura, Yuto Yamada, Kensuke Yoshimoto, Seiichi Hara, Yui Kishimoto, Takahisa Matsuda, Yoshinori Igarashi   +11 more
doaj   +1 more source

All bicovariant differential calculi on Glq(3,C) and SLq(3,C)

, 1994
All bicovariant first order differential calculi on the quantum group GLq(3,C) are determined. There are two distinct one-parameter families of calculi.
Abe E, Bresser K, Dimakis A, Dimakis A, Drinfel'd V G, Faddeev L D, Helgason S, Isaev A P, K Bresser, Maltsiniotis G, Manin Yu I, Müller-Hoissen F, Müller-Hoissen F, Müller-Hoissen F, Pflaum M J, Reshetikhin N Yu, Schirrmacher A, Schmüdgen K, Schmüdgen K, Sun X, Sweedler M E, Zumino B   +21 more
core   +2 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Pathogenesis and prevention of residual gall bladder: Report of three cases and review of literature

Archives of Medicine and Health Sciences, 2014
Cholecystectomy is a common surgery performed for uncomplicated symptomatic gall stones as a definitive procedure. For complicated cases, partial or modified subtotal cholecystectomy has been described as an easy, safe, and definitive option.
Usha Dalal, Ashwani Kumar Dalal, Rikki Singal, Ashok Kumar Attri, Gautam Mendiratta   +4 more
doaj   +1 more source