Results 91 to 100 of about 76,910 (285)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

EXPTIME Tableaux for the Coalgebraic Mu-Calculus

, 2009
The coalgebraic approach to modal logic provides a uniform framework that captures the semantics of a large class of structurally different modal logics, including e.g. graded and probabilistic modal logics and coalition logic.
Pattinson, Dirk, Cirstea, Corina, Kupke, Clemens   +2 more
core   +1 more source

ДРОБНОЕ ИСЧИСЛЕНИЕ И АППРОКСИМАЦИОННЫЕ МЕТОДЫ В МОДЕЛИРОВАНИИ ДИНАМИЧЕСКИХ СИСТЕМ [PDF]

, 2008
Книга посвящена аппроксимационно-операционным методам моделирования динамических систем дробного и смешанного порядков. Рассмотрены методы аппроксимации сигналов обобщенными полиномами с различными системами базисных функций, построение на основе этих ...
Симак, Лилия Алексеевна, Васильев, Всеволод Викторович   +1 more
core   +1 more source

Calculus in Non-Integer-Dimensional Space: Tool for Fractal Physics

Fractal and Fractional
Integration in non-integer-dimensional spaces (NIDS) is actively used in quantum field theory, statistical physics, and fractal media physics. The integration over the entire momentum space with non-integer dimensions was first proposed by Wilson in 1973
Vasily E. Tarasov
doaj   +1 more source

Complexity results for modal logic with recursion via translations and tableaux [PDF]

Logical Methods in Computer Science
This paper studies the complexity of classical modal logics and of their extension with fixed-point operators, using translations to transfer results across logics. In particular, we show several complexity results for multi-agent logics via translations
Luca Aceto, Antonis Achilleos, Elli Anastasiadi, Adrian Francalanza, Anna Ingólfsdóttir   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Applications of a metaplectic calculus to Schrödinger evolutions with non-self-adjoint generators [PDF]

, 2018
International audienceApplications of a metaplectic calculus to Schrödinger evolutions with non-self-adjoint generators Abstract We review the calculus of metaplectic operators and shifts in phase space applied to Gaussian wave packets. Using holomorphic
Viola, Joe, Joe Viola
core   +1 more source

Loop-check elimination for non-transitive distributed knowledge logic

Lietuvos Matematikos Rinkinys, 2008
A non-transitive distributed knowledge logic TnD, obtained from multi-modal logic Tn by adding distributed knowledge operator, is considered. Sound and complete loop-check-free sequent calculus for this logic is proposed.
Aida Pliuškevičienė
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source