Results 121 to 130 of about 76,910 (285)
Background College readiness is declining, increasing the number of students entering college with low math proficiency. These students are historically unable to make progress towards learning engineering skills until they’ve completed remedial math coursework and have low retention and graduation rates.
Anika Pirkey +3 more
openaire +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
, 2000 Rapport interne.The Rho-calculus is a new calculus that integrates in a uniform and simple setting first-order rewriting, lambda-calculus and non-deterministic computations. This paper describes the calculus from its syntax to its basic properties in the
Kirchner, Claude, Cirstea, Horatiu
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Semi-Substructural Logics à la Lambek with Symmetry
Bulletin of the Section of LogicThis work studies the proof theory and ternary relational semantics of left (right) skew monoidal closed categories and skew monoidal bi-closed categories, both symmetric and non-symmetric, from the perspective of non-associative Lambek calculus ...
Cheng-Syuan Wan
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Calculus Students\u27 Understanding of Area and Volume in Non-calculus Contexts
, 2012 Researchers have documented difficulties that elementary school students have in understanding area and volume. Although area and volume show up in various ways later in the curriculum, we know very little about older students\u27 understanding of these ...
Dorko, Allison J.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source