Results 231 to 240 of about 751,666 (339)

A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness

open access: yesAdvanced Science, EarlyView.
This study identifies a sub‐circuit within the circadian pacemaker suprachiasmatic nucleus (SCN) that promotes arousal. This sub‐circuit is labeled by the clock output molecule mWAKE, which suppresses its excitability in a time‐dependent manner. mWAKE‐expressing cells in the SCN (SCNmWAKE cells) project to the subparaventricular zone (SPZ) to mediate ...
Qiang Liu   +6 more
wiley   +1 more source

Forelimb Motor Learning and Memory Consolidation Drives Distinct Oligodendrocyte Plasticity to Regulate Task‐related Neuronal Activity

open access: yesAdvanced Science, EarlyView.
Genetic and chemical tracking of oligodendrogenesis, combining fiber photometric neuronal activity recording, reveals that distinct oligodendrocyte plasticities are adopted during different phases of motor learning to fine‐tune task‐related neuronal activity, with a preferential involvement of oligodendrogenesis suppression and node lengthening (type 2
Shuming Wang   +10 more
wiley   +1 more source

LPS‐Induced Mitochondrial Damage via SLC41A1‐Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells

open access: yesAdvanced Science, EarlyView.
Lipopolysaccharide induces upregulation of the magnesium (Mg2+) efflux transporter solute carrier family 41 member 1 in dental stem cells, leading to a decrease in intracellular Mg2+ concentration and promoting the binding of oligomycin sensitivity‐conferring protein and cyclophilinD.
Yuan Liu   +11 more
wiley   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

open access: yesAdvanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi   +10 more
wiley   +1 more source

Mechano‐Bactericidal Surfaces Achieved by Epitaxial Growth of Metal–Organic Frameworks

open access: yesAdvanced Science, EarlyView.
Mechano‐bactericidal surfaces based on metal–organic frameworks (MOFs) are designed using a MOF‐on‐MOF strategy. Two methods of MOF surface assembly, in situ growth and ex situ dropcasting, are applied. Distinct mechano‐bactericidal actions are discussed, including stretching, impaling, and mechanical injury. Abstract Mechano‐bactericidal (MB) surfaces
Zhejian Cao   +7 more
wiley   +1 more source

Clinical Applications of Artificial Intelligence in Periodontology: A Scoping Review. [PDF]

open access: yesMedicina (Kaunas)
Chatzopoulos GS   +3 more
europepmc   +1 more source

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