Results 41 to 50 of about 13,733 (253)
Multibump solutions for an almost periodically forced singular Hamiltonian system
Electronic Journal of Differential Equations, 1995 existence of so-called multibump homoclinic solutions for a family of singular Hamiltonian systems in $R^2$ which are subjected to almost periodic forcing in time.
Paul H. Rabinowitz
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Existence and multiplicity results for homoclinic orbits of Hamiltonian systems
Electronic Journal of Differential Equations, 1997 Homoclinic orbits play an important role in the study of qualitative behavior of dynamical systems. Such kinds of orbits have been studied since the time of Poincare.
Chao-Nien Chen, Shyuh-Yaur Tzeng
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Periodic Solutions for a Class of 2n-Order Ordinary Differential Equations
MathematicsPeriodic solutions of high-order nonlinear differential equations are fundamental in dynamical systems, yet they remain challenging to establish with traditional methods.
Wenjin Li, Jiaxuan Sun, Yanni Pang
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Euler-Lagrange equation for a delay variational problem
Nonautonomous Dynamical Systems, 2017 We establish Euler-Lagrange equations for a problem of Calculus of Variations where the unknown variable contains a term of delay on a ...
Blot Joël, Koné Mamadou I.
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Variational and penalization methods for studying connecting orbits of Hamiltonian systems
Electronic Journal of Differential Equations, 2000 In this article, we consider a class of second order Hamiltonian systems that possess infinite or finite number of equilibria. Variational arguments will be used to study the existence of connecting orbits joining pairs of equilibria.
Chao-Nien Chen, Shyuh-yaur Tzeng
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