Results 61 to 70 of about 153,025 (273)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
The classical theory of calculus of variations for generalized functions
Advances in Nonlinear Analysis, 2017 We present an extension of the classical theory of calculus of variations to generalized functions. The framework is the category of generalized smooth functions, which includes Schwartz distributions, while sharing many nonlinear properties with ...
Lecke Alexander +2 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Variational and penalization methods for studying connecting orbits of Hamiltonian systems
Electronic Journal of Differential Equations, 2000 In this article, we consider a class of second order Hamiltonian systems that possess infinite or finite number of equilibria. Variational arguments will be used to study the existence of connecting orbits joining pairs of equilibria.
Chao-Nien Chen, Shyuh-yaur Tzeng
doaj
Euler-Lagrange equation for a delay variational problem
Nonautonomous Dynamical Systems, 2017 We establish Euler-Lagrange equations for a problem of Calculus of Variations where the unknown variable contains a term of delay on a ...
Blot Joël, Koné Mamadou I.
doaj +1 more source
Geometric aspects of higher order variational principles on submanifolds
, 2008 The geometry of jets of submanifolds is studied, with special interest in the relationship with the calculus of variations. A new intrinsic geometric formulation of the variational problem on jets of submanifolds is given.
Manno, Gianni, Vitolo, Raffaele
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Sobolev inequalities in 2-D hyperbolic space: A borderline case
Journal of Inequalities and Applications, 1998 Sobolev inequalities in two-dimensional hyperbolic space are dealt with. Here is modeled on the upper Euclidean. half-plane equipped with the Poincaré–Bergman metric.
Mugelli Francesco, Talenti Giorgio
doaj
The Generalized Fractional Calculus of Variations
, 2014 We review the recent generalized fractional calculus of variations. We consider variational problems containing generalized fractional integrals and derivatives and study them using indirect methods.
Odzijewicz, Tatiana +1 more
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source