Results 81 to 90 of about 166,028,341 (301)
Advances in Nonlinear Analysis, 2017 The core of this paper concerns the existence (via regularity) of weak solutions in W01,2${W_{0}^{1,2}}$ of a class of elliptic systems such ...
Boccardo Lucio, Orsina Luigi
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Scientific computation of conservation laws in the calculus of variations and optimal control
, 2005 We present analytic computational tools that permit us to identify, in an automatic way, conservation laws in optimal control. The central result we use is the famous Noether’s theorem, a classical theory developed by Emmy Noether in 1918, in the ...
Gouveia, Paulo D.F., Torres, Delfim F.M.
core
Calculus of Variations: Nature's Parsimonious Self-Computation
, 2023 In addition to being intrinsically interesting, calculus of variations constitutes an area that has been extensively considered in both theoretic and applied areas, underlying a large number of structures and phenomena, including the stationary action ...
da Fontoura Costa, Luciano
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Fractional Calculus of Variations for Composed Functionals with Generalized Derivatives
Fractal and FractionalThis paper extends the fractional calculus of variations to include generalized fractional derivatives with dependence on a given kernel, encompassing a wide range of fractional operators.
Ricardo Almeida
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Optimal Feeding Trajectories Design for E. coli Fed-batch Fermentations [PDF]
International Journal Bioautomation, 2010 In this paper optimal control algorithms for two E. coli fed-batch fermentations are developed. Fed-batch fermentation processes of E. coli strain MC4110 and E. coli strain BL21(DE3)pPhyt109 are considered.
Olympia Roeva +2 more
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source